Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Ryan P. Hobbs; Susan H. Smith; Spiro Getsios

doi:10.1016/j.jid.2017.01.023

Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Ryan P. Hobbs, Susan H. Smith, Spiro Getsios

Research output: Contribution to journal › Comment/debate › peer-review

5 Scopus citations

Abstract

Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

Original language	English (US)
Pages (from-to)	1410-1412
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	7
DOIs	https://doi.org/10.1016/j.jid.2017.01.023
State	Published - Jul 2017

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2017.01.023

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title = "Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes",

abstract = "Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.",

author = "Hobbs, {Ryan P.} and Smith, {Susan H.} and Spiro Getsios",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = jul,

doi = "10.1016/j.jid.2017.01.023",

language = "English (US)",

volume = "137",

pages = "1410--1412",

journal = "Journal of Investigative Dermatology",

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TY - JOUR

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T2 - A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

AU - Hobbs, Ryan P.

AU - Smith, Susan H.

AU - Getsios, Spiro

PY - 2017/7

Y1 - 2017/7

N2 - Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

AB - Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.

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U2 - 10.1016/j.jid.2017.01.023

DO - 10.1016/j.jid.2017.01.023

M3 - Comment/debate

C2 - 28390815

AN - SCOPUS:85021331021

SN - 0022-202X

VL - 137

SP - 1410

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 7

ER -

Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Abstract

All Science Journal Classification (ASJC) codes

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