Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes

Keyphrases

• Alcohol 100%
• Mammalian Target of Rapamycin (mTOR) 100%
• C2C12 Myocytes 100%
• Tuberous Sclerosis Complex 100%
• Phospholipase D 100%
• Phosphatidic Acid 100%
• AMP-activated Protein Kinase 100%
• Ethanol 66%
• Phospholipase D Activity 41%
• Phosphorylation 25%
• Assay Kit 16%
• Immunoblotting 16%
• Phosphoinositide 3-kinase (PI3K) 16%
• Incubation 8%
• Well-defined 8%
• Protein-protein Interaction 8%
• Protein Complex 8%
• Feedback Loop 8%
• Non-associated 8%
• S6 Kinase 1 (S6K1) 8%
• Phosphorylation State 8%
• Co-immunoprecipitation (co-IP) 8%
• Signaling Cascades 8%
• Akt Phosphorylation 8%
• Myocytes 8%
• Adverse Effects 8%
• Regulatory Proteins 8%
• Muscle Protein Synthesis 8%
• Acid Concentration 8%
• GTPase 8%
• Wortmannin 8%
• C2C12 Myoblasts 8%
• Rheb 8%
• Tuberous Sclerosis 8%
• Rictor 8%
• Amplex Red 8%
• DEPTOR 8%
• RagC 8%
• Raga 8%

Biochemistry, Genetics and Molecular Biology

• AMP-activated Protein Kinase 100%
• C2C12 100%
• TSC2 100%
• Phospholipase D 100%
• Phosphoinositide 3-Kinase 16%
• Western Blot 16%
• Protein Complexes 8%
• Metabolite 8%
• Protein-Protein Interaction 8%
• Protein Biosynthesis 8%
• Mammalian Target of Rapamycin 8%
• Immunoprecipitation 8%
• Mammalian Target of Rapamycin Complex 1 8%
• GTPase 8%
• mTOR Signaling 8%
• Tuberous Sclerosis 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Ethanol 100%
• Hydroxymethylglutaryl Coenzyme A Reductase Kinase 100%
• Phospholipase D 100%
• Phosphatidic Acid 100%
• Phosphatidylinositol 3 Kinase 16%
• Western Blot 16%
• Epileptic Absence 8%
• Adverse Event 8%
• Immunoprecipitation 8%
• Wortmannin 8%
• Regulator Protein 8%
• Muscle Protein 8%
• Tuberin 8%
• Guanosine Triphosphatase 8%
• Mammalian Target of Rapamycin Complex 1 8%