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Activation of trans-l,2-dihydro-l,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450

  • Hiroshi Yamazaki
  • , Mayumi Mimura
  • , Yoshimitsu Oda
  • , Frank J. Gonzalez
  • , Karam El-bayoumy
  • , Young Heum Chae
  • , F. Peter Guengerich
  • , Tsutomu Shimada

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Pharmacology, Toxicology and Pharmaceutical Science