Active and latent forms of transforming growth factor β activity in synovial effusions

R. Fava; N. Olsen; J. Keski-Oja; H. Moses; T. Pincus

doi:10.1084/jem.169.1.291

Active and latent forms of transforming growth factor β activity in synovial effusions

R. Fava
, N. Olsen
, J. Keski-Oja
, H. Moses
, T. Pincus

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

Original language	English (US)
Pages (from-to)	291-296
Number of pages	6
Journal	Journal of Experimental Medicine
Volume	169
Issue number	1
DOIs	https://doi.org/10.1084/jem.169.1.291
State	Published - 1989

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1084/jem.169.1.291

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abstract = "We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.",

author = "R. Fava and N. Olsen and J. Keski-Oja and H. Moses and T. Pincus",

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AU - Olsen, N.

AU - Keski-Oja, J.

AU - Moses, H.

AU - Pincus, T.

PY - 1989

Y1 - 1989

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AB - We have evaluated the possible involvement of TGF-β in rheumatoid arhritis by assay of 16 cell-free synovial fluids for the presence of its active and 'latent forms'. Evidence has been obtained for TGF-β-like activity in synovial effusions by four criteria: (a) TGF-β receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

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ER -

Active and latent forms of transforming growth factor β activity in synovial effusions

Abstract

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