Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling

Keyphrases

• Active Role 5%
• Active Sites 100%
• Adenosine Monophosphate 100%
• Amides 11%
• Begging the Question 5%
• Binding Partners 5%
• Binding Site 5%
• Cellular Response 5%
• Computational Docking 17%
• Cyclic nucleotide Phosphodiesterase 5%
• Desensitization 5%
• Direct Interaction 11%
• Dissociation 29%
• High Affinity 11%
• Hormonal Stimulation 5%
• Hydrogen-deuterium Exchange Mass Spectrometry 17%
• Hydrolysis 11%
• Interaction Interface 5%
• Ligand-binding Domain 5%
• Local Concentration 5%
• Mammalian System 5%
• Microdomain 5%
• Phosphodiesterase 100%
• Protein Complex 5%
• Protein Kinase 100%
• Protein Kinase Signaling 5%
• Receptor-interacting Protein Kinase 1 (RIPK1) 5%
• Regulatory Pathways 5%
• Regulatory Subunit 17%
• Signal Termination 11%
• Signaling Molecules 5%
• Signaling State 5%
• Structural Mass Spectrometry 5%
• Substrate Channeling 5%

Biochemistry, Genetics and Molecular Biology

• Active Site 100%
• Adenosine Monophosphate 100%
• Binding Domain 5%
• Binding Site 5%
• Cyclic Nucleotide Phosphodiesterase 5%
• Dynamics 5%
• Enzymatic Hydrolysis 11%
• Hydrogen/Deuterium Exchange Mass Spectrometry 17%
• Isoform 5%
• Mass Spectrometry 5%
• Phosphodiesterase 100%
• Protein Complexes 5%
• Protein Kinases 100%
• Signaling Protein 5%
• Substrate Channeling 5%