Active site labeling of the gentamicin resistance enzyme AAC(6’)-APH(2”) by the lipid kinase inhibitor wortmannin

Keyphrases

• Wortmannin 100%
• APH-2 100%
• Resistance Enzymes 100%
• Active Site Labeling 100%
• Active Site Structure 40%
• Protein Kinase 20%
• Active Sites 20%
• Molecular Mechanism 20%
• Lysine 20%
• Kinase Activity 20%
• ATP Analogues 20%
• Aminoglycoside Antibiotics 20%
• Covalent Modification 20%
• Protein Kinase Inhibitors 20%
• Site-directed 20%
• Adenosine 20%
• ATP-binding Pocket 20%
• Bifunctional Enzyme 20%
• ATP Binding Site 20%
• Phosphatidylinositol 3-kinase Inhibitor 20%
• Antibiotic Resistance 20%
• Labeling Method 20%
• Electrophilic 20%
• Aminoglycosides 20%
• Deacetylase Activity 20%
• Aminoglycoside Resistance 20%
• Functional Similarity 20%
• Benzoyl 20%
• Enzyme Active Site 20%
• Inactivator 20%
• Antibiotic Resistance Mechanisms 20%
• 2-structure 20%
• Lipid Kinase 20%
• Aminoglycoside Acetyltransferase 20%

Biochemistry, Genetics and Molecular Biology

• Lipid 100%
• Kinase 100%
• Phosphotransferase 100%
• Active Site 100%
• Enzyme 100%
• Gentamicin 100%
• Adenosine Triphosphate 42%
• Aminoglycoside 42%
• Antibiotic Resistance 28%
• Binding Site 14%
• Enzyme Active Site 14%
• Aminoglycoside Antibiotics 14%
• Phosphoinositide 3-Kinase Inhibitor 14%
• N-Acetyltransferase 14%
• Electrophilicity 14%
• Labeling Technique 14%
• Lysine 14%
• Adenosine 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine Triphosphate 100%
• Gentamicin 100%
• Phosphotransferase Inhibitor 100%
• Wortmannin 100%
• Aminoglycoside 100%
• Phosphotransferase 66%
• Antimicrobial Resistance 66%
• Binding Site 33%
• Adenosine 33%
• Lysine 33%
• Phosphatidylinositol 3 Kinase Inhibitor 33%
• Acyltransferase 33%
• Aminoglycoside Antibiotic Agent 33%