TY - JOUR
T1 - Activity-related behaviors in the hole-board predict nicotine consumption in C57B6 mice perinatally exposed to nicotine
AU - Gyekis, Joseph
AU - Foreman, Jennifer E.
AU - Anthony, Kate
AU - Klein, Laura Cousino
AU - Vandenbergh, David J.
PY - 2010/1/5
Y1 - 2010/1/5
N2 - Hole-board behaviors of adolescent C57B/6 mice that had been exposed to nicotine during gestation and suckling were evaluated on postnatal days 34-36. Rearing on all three trials significantly predicted higher nicotine intake on a two-bottle choice test administered from days 37-42. For head pokes, there was a weak trend for lower head poking in the first trial to be predictive of higher nicotine intake. Locomotor activity only predicted higher nicotine consumption on the third trial. These results show that hole-board behaviors predict subsequent nicotine intake in mice exposed to nicotine perinatally, especially after habituation to the apparatus.
AB - Hole-board behaviors of adolescent C57B/6 mice that had been exposed to nicotine during gestation and suckling were evaluated on postnatal days 34-36. Rearing on all three trials significantly predicted higher nicotine intake on a two-bottle choice test administered from days 37-42. For head pokes, there was a weak trend for lower head poking in the first trial to be predictive of higher nicotine intake. Locomotor activity only predicted higher nicotine consumption on the third trial. These results show that hole-board behaviors predict subsequent nicotine intake in mice exposed to nicotine perinatally, especially after habituation to the apparatus.
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U2 - 10.1016/j.bbr.2009.08.024
DO - 10.1016/j.bbr.2009.08.024
M3 - Article
C2 - 19715729
AN - SCOPUS:70350188307
SN - 0166-4328
VL - 206
SP - 139
EP - 142
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -