Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion: A pilot study

Steven M. Mirin; Jack H. Mendelson; James Ellingboe; Roger E. Meyer

doi:10.1016/0306-4530(76)90004-4

Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion: A pilot study

Steven M. Mirin, Jack H. Mendelson, James Ellingboe, Roger E. Meyer

Department of Psychiatry and Behavioral Health

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

(1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.

Original language	English (US)
Pages (from-to)	359-369
Number of pages	11
Journal	Psychoneuroendocrinology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0306-4530(76)90004-4
State	Published - 1976

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0306-4530(76)90004-4

Cite this

@article{84cce2d48a8c4def9f2ba8ac5c77fead,

title = "Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion: A pilot study",

abstract = "(1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.",

author = "Mirin, {Steven M.} and Mendelson, {Jack H.} and James Ellingboe and Meyer, {Roger E.}",

year = "1976",

doi = "10.1016/0306-4530(76)90004-4",

language = "English (US)",

volume = "1",

pages = "359--369",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion

T2 - A pilot study

AU - Mirin, Steven M.

AU - Mendelson, Jack H.

AU - Ellingboe, James

AU - Meyer, Roger E.

PY - 1976

Y1 - 1976

N2 - (1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.

AB - (1) Two detoxified male heroin addicts were given 10 mg of intravenous heroin and experienced a rapid fall in plasma LH. FSH levels were unchanged. (2) Approximately 4 hr after LH suppression (by heroin), plasma testosterone levels also dropped markedly. (3) Naltrexone pretreatment prevented opiate-induced suppression of both LH and testosterone. (4) Instead, an increased number of secretory bursts of LH occurred after naltrexone administration, and mean plasma LH levels were higher than those obtained during a saline control period. (5) Testosterone and FSH secretion were not appreciably affected by naltrexone treatment.

UR - http://www.scopus.com/inward/record.url?scp=0017148095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017148095&partnerID=8YFLogxK

U2 - 10.1016/0306-4530(76)90004-4

DO - 10.1016/0306-4530(76)90004-4

M3 - Article

AN - SCOPUS:0017148095

SN - 0306-4530

VL - 1

SP - 359

EP - 369

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

IS - 4

ER -

Acute effects of heroin and naltrexone on testosterone and gonadotropin secretion: A pilot study

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this