TY - JOUR
T1 - Acute endophthalmitis following intravitreal triamcinolone acetonide injection
AU - Moshfeghi, Darius M.
AU - Kaiser, Peter K.
AU - Scott, Ingrid U.
AU - Sears, Jonathan E.
AU - Benz, Matthew
AU - Sinesterra, Juan P.
AU - Kaiser, Richard S.
AU - Bakri, Sophie J.
AU - Maturi, Raj K.
AU - Belmont, Jonathan
AU - Beer, Paul M.
AU - Murray, Timothy G.
AU - Quiroz-Mercado, Hugo
AU - Mieler, William F.
N1 - Funding Information:
Supported, in part, by The Ronald G. Michels Fellowship Foundation, Baltimore, MD (D.M.M.) and Diabetes Association of Greater Cleveland (P.K.K.).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/11
Y1 - 2003/11
N2 - • PURPOSE: To report the clinical features, causative organisms, management, and visual acuity outcomes of eight eyes of eight patients who developed acute postoperative endophthalmitis following intravitreal injection of triamcinolone acetonide (IVTA). • DESIGN: Retrospective, multicenter, interventional, case series. • METHODS: A retrospective, interventional, case series of all patients with acute postoperative endophthalmitis following IVTA at seven academic clinical centers between March 2001 and July 2002. • RESULTS: A total of 922 IVTAs were performed. Eight eyes of eight patients with acute postoperative endophthalmitis were identified in the 6 weeks following IVTA for an incidence of 0.87% (95% confidence interval of 0. 38% to 1.70%). The median time to presentation was 7.5 days (range, 1-15 days) after IVTA. The most common clinical findings were iritis (n = 8), vitritis (n = 8), hypopyon (n = 8), pain (n = 7), red eye (n = 6), and decreased vision (n = 5). The median presenting visual acuity was 20/1127 (range, 20/60 to light perception). Initial treatment consisted of vitreous tap and injection of antibiotics (n = 6) or pars plana vitrectomy and injection of intravitreal antibiotics (n = 2). Intraocular cultures yielded identification in seven patients. One demonstrated intracellular gram-positive cocci in chains with numerous polymorphonuclear cells on gram stain. The median postinfection vision was 20/400 (range, 20/40 to no light perception). Three patients ended up with no light perception visual acuity, including enucleation (n = 1) and phthisis (n = 1). • CONCLUSIONS: Acute postoperative endophthalmitis following IVTA occurs rapidly and can result in severe loss of vision.
AB - • PURPOSE: To report the clinical features, causative organisms, management, and visual acuity outcomes of eight eyes of eight patients who developed acute postoperative endophthalmitis following intravitreal injection of triamcinolone acetonide (IVTA). • DESIGN: Retrospective, multicenter, interventional, case series. • METHODS: A retrospective, interventional, case series of all patients with acute postoperative endophthalmitis following IVTA at seven academic clinical centers between March 2001 and July 2002. • RESULTS: A total of 922 IVTAs were performed. Eight eyes of eight patients with acute postoperative endophthalmitis were identified in the 6 weeks following IVTA for an incidence of 0.87% (95% confidence interval of 0. 38% to 1.70%). The median time to presentation was 7.5 days (range, 1-15 days) after IVTA. The most common clinical findings were iritis (n = 8), vitritis (n = 8), hypopyon (n = 8), pain (n = 7), red eye (n = 6), and decreased vision (n = 5). The median presenting visual acuity was 20/1127 (range, 20/60 to light perception). Initial treatment consisted of vitreous tap and injection of antibiotics (n = 6) or pars plana vitrectomy and injection of intravitreal antibiotics (n = 2). Intraocular cultures yielded identification in seven patients. One demonstrated intracellular gram-positive cocci in chains with numerous polymorphonuclear cells on gram stain. The median postinfection vision was 20/400 (range, 20/40 to no light perception). Three patients ended up with no light perception visual acuity, including enucleation (n = 1) and phthisis (n = 1). • CONCLUSIONS: Acute postoperative endophthalmitis following IVTA occurs rapidly and can result in severe loss of vision.
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U2 - 10.1016/S0002-9394(03)00483-5
DO - 10.1016/S0002-9394(03)00483-5
M3 - Article
C2 - 14597028
AN - SCOPUS:10744233542
SN - 0002-9394
VL - 136
SP - 791
EP - 796
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 5
ER -