Adaption by Rewiring Epigenetic Landscapes

Yifei Liu; Andrew Xiao

doi:10.1016/j.stem.2015.08.015

Adaption by Rewiring Epigenetic Landscapes

Yifei Liu, Andrew Xiao

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

Original language	English (US)
Article number	1841
Pages (from-to)	249-250
Number of pages	2
Journal	Cell Stem Cell
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2015.08.015
State	Published - Sep 3 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2015.08.015

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title = "Adaption by Rewiring Epigenetic Landscapes",

abstract = "Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.",

author = "Yifei Liu and Andrew Xiao",

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year = "2015",

month = sep,

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doi = "10.1016/j.stem.2015.08.015",

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AU - Liu, Yifei

AU - Xiao, Andrew

PY - 2015/9/3

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AB - Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

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ER -

Adaption by Rewiring Epigenetic Landscapes

Abstract

All Science Journal Classification (ASJC) codes

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