Adaption by Rewiring Epigenetic Landscapes

Yifei Liu, Andrew Xiao

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Embryonic stem cells (ESCs) generally rely on repressive histone modifications to silence retrotransposons, rather than DNA methylation as in differentiated cells. In this issue of Cell Stem Cell, He et al. (2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.

Original languageEnglish (US)
Article number1841
Pages (from-to)249-250
Number of pages2
JournalCell Stem Cell
Volume17
Issue number3
DOIs
StatePublished - Sep 3 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

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