TY - JOUR
T1 - Addiction Research Consortium
T2 - Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions
AU - Heinz, Andreas
AU - Kiefer, Falk
AU - Smolka, Michael N.
AU - Endrass, Tanja
AU - Beste, Christian
AU - Beck, Anne
AU - Liu, Shuyan
AU - Genauck, Alexander
AU - Romund, Lydia
AU - Banaschewski, Tobias
AU - Bermpohl, Felix
AU - Deserno, Lorenz
AU - Dolan, Raymond J.
AU - Durstewitz, Daniel
AU - Ebner-Priemer, Ulrich
AU - Flor, Herta
AU - Hansson, Anita C.
AU - Heim, Christine
AU - Hermann, Derik
AU - Kiebel, Stefan
AU - Kirsch, Peter
AU - Kirschbaum, Clemens
AU - Koppe, Georgia
AU - Marxen, Michael
AU - Meyer-Lindenberg, Andreas
AU - Nagel, Wolfgang E.
AU - Noori, Hamid R.
AU - Pilhatsch, Maximilian
AU - Priller, Josef
AU - Rietschel, Marcella
AU - Romanczuk-Seiferth, Nina
AU - Schlagenhauf, Florian
AU - Sommer, Wolfgang H.
AU - Stallkamp, Jan
AU - Ströhle, Andreas
AU - Stock, Ann Kathrin
AU - Winterer, Georg
AU - Winter, Christine
AU - Walter, Henrik
AU - Witt, Stephanie
AU - Vollstädt-Klein, Sabine
AU - Rapp, Michael A.
AU - Tost, Heike
AU - Spanagel, Rainer
N1 - Funding Information:
We established a collaborative research center (CRC) in mid‐2019, which brings together scientists with complementary expertise in addiction research from three internationally recognized centers (Charité Berlin, Technical University of Dresden, and Central Institute of Mental Health in Mannheim) in Germany. Our multidisciplinary (ReCoDe) consortium consists of 40 principal investigators (PIs) and it will be substantially funded for up to 12 years (three 4‐year funding periods) by the German Research Foundation (DFG). The consortium integrates a range of fields, including psychology, medicine, computation and machine learning, and neurobiology, allowing experts (for clinical and animal studies) to move basic science discoveries into practice. Losing and Regaining Control over Drug Intake
Funding Information:
The Collaborative Research Center (CRC) (Transregio - TRR 265 - Losing and regaining control over drug intake—from trajectories to mechanisms and interventions) is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft DFG).
Publisher Copyright:
© 2019 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction
PY - 2020/3/1
Y1 - 2020/3/1
N2 - One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
AB - One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
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U2 - 10.1111/adb.12866
DO - 10.1111/adb.12866
M3 - Article
C2 - 31859437
AN - SCOPUS:85076764754
SN - 1355-6215
VL - 25
JO - Addiction Biology
JF - Addiction Biology
IS - 2
M1 - e12866
ER -