Adhesive colonization of biomaterials and antibiotic resistance

Anthony G. Gristina; Cherri D. Hobgood; Lawrence X. Webb; Quentin N. Myrvik

doi:10.1016/0142-9612(87)90077-9

Adhesive colonization of biomaterials and antibiotic resistance

Anthony G. Gristina, Cherri D. Hobgood, Lawrence X. Webb, Quentin N. Myrvik

Department of Emergency Medicine

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermidis were well above normal.

Original language	English (US)
Pages (from-to)	423-426
Number of pages	4
Journal	Biomaterials
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0142-9612(87)90077-9
State	Published - Nov 1987

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/0142-9612(87)90077-9

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AB - This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermidis were well above normal.

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Adhesive colonization of biomaterials and antibiotic resistance

Abstract

All Science Journal Classification (ASJC) codes

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