Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Carla M. Ward; Harumi Jyonouchi; Sergei V. Kotenko; Sergey V. Smirnov; Rakesh Patel; Helen Aguila; George McSherry; Barry Dashefsky; Steven M. Holland

doi:10.1007/s00431-006-0339-1

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Carla M. Ward, Harumi Jyonouchi, Sergei V. Kotenko, Sergey V. Smirnov, Rakesh Patel, Helen Aguila, George McSherry, Barry Dashefsky, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We report adjunct treatment of (interferon) IFN-α2b (Intron-A) in a patient with complete interferon-γ receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-α2b (3 × 10⁶ units/m² three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/ retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-α2b for disseminated MAC infection.

Original language	English (US)
Pages (from-to)	981-985
Number of pages	5
Journal	European Journal of Pediatrics
Volume	166
Issue number	9
DOIs	https://doi.org/10.1007/s00431-006-0339-1
State	Published - Sep 2007

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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Ward, C. M., Jyonouchi, H., Kotenko, S. V., Smirnov, S. V., Patel, R., Aguila, H., McSherry, G., Dashefsky, B., & Holland, S. M. (2007). Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. European Journal of Pediatrics, 166(9), 981-985. https://doi.org/10.1007/s00431-006-0339-1

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title = "Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency",

abstract = "We report adjunct treatment of (interferon) IFN-α2b (Intron-A) in a patient with complete interferon-γ receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-α2b (3 × 106 units/m2 three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/ retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-α2b for disseminated MAC infection.",

author = "Ward, {Carla M.} and Harumi Jyonouchi and Kotenko, {Sergei V.} and Smirnov, {Sergey V.} and Rakesh Patel and Helen Aguila and George McSherry and Barry Dashefsky and Holland, {Steven M.}",

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Ward, CM, Jyonouchi, H, Kotenko, SV, Smirnov, SV, Patel, R, Aguila, H, McSherry, G, Dashefsky, B & Holland, SM 2007, 'Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency', European Journal of Pediatrics, vol. 166, no. 9, pp. 981-985. https://doi.org/10.1007/s00431-006-0339-1

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. / Ward, Carla M.; Jyonouchi, Harumi; Kotenko, Sergei V. et al.
In: European Journal of Pediatrics, Vol. 166, No. 9, 09.2007, p. 981-985.

Research output: Contribution to journal › Article › peer-review

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AU - Ward, Carla M.

AU - Jyonouchi, Harumi

AU - Kotenko, Sergei V.

AU - Smirnov, Sergey V.

AU - Patel, Rakesh

AU - Aguila, Helen

AU - McSherry, George

AU - Dashefsky, Barry

AU - Holland, Steven M.

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Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

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