Adjuvant radiation and outcomes after breast conserving surgery in publicly insured patients

Gretchen G. Kimmick, Fabian Camacho, Wenke Hwang, Heath Mackley, John Stewart, Roger T. Anderson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives: Epidemiologic studies report that lack of adjuvant radiation (RT) after breast conserving surgery (BCS) is associated with higher short-term mortality. It is generally accepted that adjuvant RT decreases risk of breast cancer recurrence and thereby lowers long-term mortality; here, we explore reasons for its relationship to short-term mortality. Materials and Methods: We studied 1583 publically insured women who had BCS between 1998 and 2002 (mean 71.8. years, range 27-101), of whom 1346 (85%) received RT. Multivariate analyses with Cox Proportional Hazards and Logistic Regression models included: age; race; comorbidity; insurance status; tumor size; number of nodes positive; hormone receptor status; receipt of radiation; adjuvant chemotherapy; preventive care - including mammography, Pap smear and primary care visits; and hospitalization. Results: At a mean follow-up of 52.8. months, overall mortality was significantly lower in those who received RT (HR 0.45, p < 0.0001) and higher with older age (HR 1.05, p < 0.0001) and greater comorbidity (HR 1.16, p = 0.0007). Local recurrence was less with receipt of optimal radiation (HR 0.47; p = 0.03). Breast cancer event, as determined by a clinically logical algorithm to detect breast cancer recurrence and death, however, was not significantly associated with receipt of RT (OR 1.32, p = 0.2). Conclusion: These results imply that the higher short-term mortality in women not receiving RT after BCS is related to factors other than breast cancer recurrence.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalJournal of Geriatric Oncology
Volume3
Issue number2
DOIs
StatePublished - Apr 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Adjuvant radiation and outcomes after breast conserving surgery in publicly insured patients'. Together they form a unique fingerprint.

Cite this