TY - JOUR
T1 - Administration of Preoperative Gabapentin to Patients Undergoing Laparoscopy
T2 - A Double-Blinded, Placebo-Controlled Randomized Trial
AU - Benton, Andrea
AU - Harkins, Gerald
AU - Stetter, Christina
AU - Kunselman, Allen
AU - Deimling, Timothy
AU - Riley, Kristin
N1 - Funding Information:
The study was supported in part by an award from The Penn State Hershey Department of Obstetrics and Gynecology.
Publisher Copyright:
© Mary Ann Liebert, Inc., publishers 2020.
PY - 2020/8
Y1 - 2020/8
N2 - Objective: The aim of this study was to determine the influence of immediate preoperative gabapentin on postoperative pain in patients undergoing laparoscopy for benign gynecologic indications. Materials and Methods: This double-blinded, placebo controlled randomized trial involved 109 gynecologic patients undergoing laparoscopy between June 2015 and January 2016 at an academic tertiary care hospital. They were randomized to receive to receive preoperative gabapentin (300 mg) or placebo. Pain scores were assessed at 2, 4, 6, and 8 hours postoperatively as well as on postoperative days 1-7. Results: The 109 patients were randomized to receive either preoperative gabapentin or placebo. The patients were stratified based on history of chronic pelvic pain. There was no difference between the groups in terms of age, body mass index, gravidity, parity, or past surgical histories. Postoperative pain was assessed with a numeric pain rating scale (NRS), rated as 0-10, and a visual analogue scale (VAS), rated as 0-100. These values were adjusted for morphine doses received. There was no significant difference in pain scores at any of the immediate postoperative hours. A secondary analysis, stratified by procedure (hysterectomy or operative laparoscopy), showed no significant differences in pain scores. There were also no significant differences in pain scores on postoperative days 1-7. Conclusions: A single dose of preoperative gabapentin did not significantly decrease postoperative pain in gynecologic patients undergoing laparoscopy for benign indications. (J GYNECOL SURG 36:173).
AB - Objective: The aim of this study was to determine the influence of immediate preoperative gabapentin on postoperative pain in patients undergoing laparoscopy for benign gynecologic indications. Materials and Methods: This double-blinded, placebo controlled randomized trial involved 109 gynecologic patients undergoing laparoscopy between June 2015 and January 2016 at an academic tertiary care hospital. They were randomized to receive to receive preoperative gabapentin (300 mg) or placebo. Pain scores were assessed at 2, 4, 6, and 8 hours postoperatively as well as on postoperative days 1-7. Results: The 109 patients were randomized to receive either preoperative gabapentin or placebo. The patients were stratified based on history of chronic pelvic pain. There was no difference between the groups in terms of age, body mass index, gravidity, parity, or past surgical histories. Postoperative pain was assessed with a numeric pain rating scale (NRS), rated as 0-10, and a visual analogue scale (VAS), rated as 0-100. These values were adjusted for morphine doses received. There was no significant difference in pain scores at any of the immediate postoperative hours. A secondary analysis, stratified by procedure (hysterectomy or operative laparoscopy), showed no significant differences in pain scores. There were also no significant differences in pain scores on postoperative days 1-7. Conclusions: A single dose of preoperative gabapentin did not significantly decrease postoperative pain in gynecologic patients undergoing laparoscopy for benign indications. (J GYNECOL SURG 36:173).
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U2 - 10.1089/gyn.2019.0102
DO - 10.1089/gyn.2019.0102
M3 - Article
AN - SCOPUS:85093110251
SN - 1042-4067
VL - 36
SP - 173
EP - 178
JO - Journal of Gynecologic Surgery
JF - Journal of Gynecologic Surgery
IS - 4
ER -