Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?

Robert A. Wild; James R. Buchanan; Cathleen Myers; Thomas Lloyd; Laurence Demers

doi:10.1016/0378-5122(87)90052-1

Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?

Robert A. Wild
, James R. Buchanan
, Cathleen Myers
, Thomas Lloyd
, Laurence Demers

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.

Original language	English (US)
Pages (from-to)	55-61
Number of pages	7
Journal	Maturitas
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0378-5122(87)90052-1
State	Published - Apr 1987

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
Obstetrics and Gynecology

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title = "Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?",

abstract = "The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.",

author = "Wild, \{Robert A.\} and Buchanan, \{James R.\} and Cathleen Myers and Thomas Lloyd and Laurence Demers",

note = "Funding Information: This work was supported in part by a grant from the Orthopaedic Research and Education Foundation as wel1 as the Core Endocrine Laboratory of the Hershey Medical Center. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1987",

month = apr,

doi = "10.1016/0378-5122(87)90052-1",

language = "English (US)",

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TY - JOUR

T1 - Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women

T2 - is there a relationship?

AU - Wild, Robert A.

AU - Buchanan, James R.

AU - Myers, Cathleen

AU - Lloyd, Thomas

AU - Demers, Laurence

N1 - Funding Information: This work was supported in part by a grant from the Orthopaedic Research and Education Foundation as wel1 as the Core Endocrine Laboratory of the Hershey Medical Center. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1987/4

Y1 - 1987/4

N2 - The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.

AB - The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.

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AN - SCOPUS:0023185603

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VL - 9

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JF - Maturitas

IS - 1

ER -

Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?

Abstract

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