Adrenal of male dog secretes androgens and estrogens

R. J. Santen, E. Samojlik, L. Demers, E. Badder

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


In the absence of functioning gonads, the adrenal is an important source of androgens and estrogens. In order to precisely quantitate the adrenal secretion rates of the sex steroids, we cannulated the adrenal veins and measured venous blood flow and arterial venous steroid gradients in adult male beagle dogs under pentobarbital anesthesia. Celite chromatography and specific radioimmunoassays were utilized to measure steroid levels. During basal conditions, the adrenal produced larger amounts of the androgens (667 ng/min) of androstenedione, 5.45 ng/min of testosterone, and 3.43 ng/min of dihydrotestosterone) than of the estrogens (1.245 ng/min of estradiol and 0.239 ng/min of estrone. These secretion rates were 20- to 50,000-fold less than that of cortisol (12,360 ng/min). Studies were also carried out during adrenal suppression with hydrocortisone to block ACTH release and with the adrenal steroidogenesis inhibitor, aminoglutethimide, plus hydrocortisone. The secretion rates of each androgen measured fell during ACTH inhibition. Significant suppression of estrone and estradiol, however, required addition of aminoglutethimide. This study provides direct evidence that the adrenal in the male dog can secrete estrogens, a previously controversial issue.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number2
StatePublished - 1980

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Adrenal of male dog secretes androgens and estrogens'. Together they form a unique fingerprint.

Cite this