Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium

Emanuele Leoncini; Walter Ricciardi; Gabriella Cadoni; Dario Arzani; Livia Petrelli; Gaetano Paludetti; Paul Brennan; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Renato Talamini; Carlo La Vecchia; Andrew F. Olshan; Deborah M. Winn; Rolando Herrero; Silvia Franceschi; Xavier Castellsague; Joshua Muscat; Hal Morgenstern; Zuo Feng Zhang; Fabio Levi; Luigino Dal Maso; Karl Kelsey; Michael McClean; Thomas L. Vaughan; Philip Lazarus; Mark P. Purdue; Richard B. Hayes; Chu Chen; Stephen M. Schwartz; Oxana Shangina; Sergio Koifman; Wolfgang Ahrens; Elena Matos; Pagona Lagiou; Jolanta Lissowska; Neonila Szeszenia-Dabrowska; Leticia Fernandez; Ana Menezes; Antonio Agudo; Alexander W. Daudt; Lorenzo Richiardi; Kristina Kjaerheim; Dana Mates; Jaroslav Betka; Guo Pei Yu; Stimson Schantz; Lorenzo Simonato; Hermann Brenner; David I. Conway; Tatiana V. Macfarlane; Peter Thomson; Eleonora Fabianova; Ariana Znaor; Peter Rudnai; Claire Healy; Paolo Boffetta; Shu Chun Chuang; Yuan Chin Amy Lee; Mia Hashibe; Stefania Boccia

doi:10.1007/s10654-013-9863-2

Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium

Emanuele Leoncini, Walter Ricciardi, Gabriella Cadoni, Dario Arzani, Livia Petrelli, Gaetano Paludetti, Paul Brennan, Daniele Luce, Isabelle Stucker, Keitaro Matsuo, Renato Talamini, Carlo La Vecchia, Andrew F. Olshan, Deborah M. Winn, Rolando Herrero, Silvia Franceschi, Xavier Castellsague, Joshua Muscat, Hal Morgenstern, Zuo Feng ZhangFabio Levi, Luigino Dal Maso, Karl Kelsey, Michael McClean, Thomas L. Vaughan, Philip Lazarus, Mark P. Purdue, Richard B. Hayes, Chu Chen, Stephen M. Schwartz, Oxana Shangina, Sergio Koifman, Wolfgang Ahrens, Elena Matos, Pagona Lagiou, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Leticia Fernandez, Ana Menezes, Antonio Agudo, Alexander W. Daudt, Lorenzo Richiardi, Kristina Kjaerheim, Dana Mates, Jaroslav Betka, Guo Pei Yu, Stimson Schantz, Lorenzo Simonato, Hermann Brenner, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Eleonora Fabianova, Ariana Znaor, Peter Rudnai, Claire Healy, Paolo Boffetta, Shu Chun Chuang, Yuan Chin Amy Lee, Mia Hashibe, Stefania Boccia

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Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Original language	English (US)
Pages (from-to)	35-48
Number of pages	14
Journal	European Journal of Epidemiology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1007/s10654-013-9863-2
State	Published - Jan 2014

All Science Journal Classification (ASJC) codes

Epidemiology

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10.1007/s10654-013-9863-2

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Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., Brennan, P., Luce, D., Stucker, I., Matsuo, K., Talamini, R., La Vecchia, C., Olshan, A. F., Winn, D. M., Herrero, R., Franceschi, S., Castellsague, X., Muscat, J., Morgenstern, H., ... Boccia, S. (2014). Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. European Journal of Epidemiology, 29(1), 35-48. https://doi.org/10.1007/s10654-013-9863-2

@article{f8bdee090ded474da26d163db4c89838,

title = "Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium",

abstract = "Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.",

author = "Emanuele Leoncini and Walter Ricciardi and Gabriella Cadoni and Dario Arzani and Livia Petrelli and Gaetano Paludetti and Paul Brennan and Daniele Luce and Isabelle Stucker and Keitaro Matsuo and Renato Talamini and {La Vecchia}, Carlo and Olshan, {Andrew F.} and Winn, {Deborah M.} and Rolando Herrero and Silvia Franceschi and Xavier Castellsague and Joshua Muscat and Hal Morgenstern and Zhang, {Zuo Feng} and Fabio Levi and {Dal Maso}, Luigino and Karl Kelsey and Michael McClean and Vaughan, {Thomas L.} and Philip Lazarus and Purdue, {Mark P.} and Hayes, {Richard B.} and Chu Chen and Schwartz, {Stephen M.} and Oxana Shangina and Sergio Koifman and Wolfgang Ahrens and Elena Matos and Pagona Lagiou and Jolanta Lissowska and Neonila Szeszenia-Dabrowska and Leticia Fernandez and Ana Menezes and Antonio Agudo and Daudt, {Alexander W.} and Lorenzo Richiardi and Kristina Kjaerheim and Dana Mates and Jaroslav Betka and Yu, {Guo Pei} and Stimson Schantz and Lorenzo Simonato and Hermann Brenner and Conway, {David I.} and Macfarlane, {Tatiana V.} and Peter Thomson and Eleonora Fabianova and Ariana Znaor and Peter Rudnai and Claire Healy and Paolo Boffetta and Chuang, {Shu Chun} and Lee, {Yuan Chin Amy} and Mia Hashibe and Stefania Boccia",

note = "Funding Information: The authors would like to thank all of the participants who took part in this research for providing us very insightful and constructive comments, which helped improve this manuscript. The individual studies were supported by the following grants: Central Europe study: World Cancer Research Fund and the European Commission INCO-COPERNICUS Program (IC15- CT98-0332). France study (2001–2007): French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Association for Research on Cancer (ARC); Fondation pour la Recherche M{\'e}dicale (FRM); French Institute for Public Health Surveillance (InVS); Fondation de France; Ministry of Labour; Ministry of Health. Saarland study: Ministry of Science, Research and Arts Baden-Wurttemberg. Aviano study: Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research. Milan study (1984–1989): Italian Association for Research on Cancer (AIRC). Milan study (2006–2009): Italian Association for Research on Cancer (AIRC, grant n. 10068) and Italian Ministry of Education (PRIN 2009 X8YCBN). Italy Multicenter study: Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research. Rome study (2010–2013): AIRC (Italian Agency for Research on Cancer), n. 10491. Swiss study: Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse (KFS-700, OCS-1633). Western Europe study: European Community (5th Framework Programme) (QLK1-CT-2001-00182). Boston study: National Institutes of Health (NIH) US (R01CA078609, R01CA100679). Los Angeles study: National Institute of Health (NIH) US (P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667) and the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center. MSKCC study: NIH (R01CA051845). New York Multicenter study: National Institutes of Health (NIH) US (P01CA068384 K07CA104231). North Carolina (1994–1997): National Institutes of Health (NIH) US (R01CA061188), and in part by a grant from the National Institute of Environmental Health Sciences (P30ES010126). Seattle-LEO study: NIH (R01CA030022). Seattle study: National Institutes of Health (NIH) US (R01CA048996, R01DE012609). Tampa study: National Institutes of Health (NIH) US (P01CA068384, K07CA104231, R01DE013158). US Multicenter study: The Intramural Program of the NCI, NIH, United States. Puerto Rico study: jointly funded by National Institutes of Health (NCI) US and NIDCR intramural programs. Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a' Pesquisa no Estado de Sao Paulo (FAPESP) (No 01/01768-2), and European Commission (IC18-CT97-0222). Japan (1988–2000 and 2001–2005): Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan (17015052) and grant for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan (H20-002). IARC Multicenter study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government (FIS 97/0024, FIS 97/0662, BAE 01/5013), International Union Against Cancer (UICC), and Yamagiwa-Yoshida Memorial International Cancer Study Grant. The work of EL was supported by Fondazione Veronesi. ",

year = "2014",

month = jan,

doi = "10.1007/s10654-013-9863-2",

language = "English (US)",

volume = "29",

pages = "35--48",

journal = "European Journal of Epidemiology",

issn = "0393-2990",

publisher = "Springer Netherlands",

number = "1",

}

Leoncini, E, Ricciardi, W, Cadoni, G, Arzani, D, Petrelli, L, Paludetti, G, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, AF, Winn, DM, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, ZF, Levi, F, Dal Maso, L, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Purdue, MP, Hayes, RB, Chen, C, Schwartz, SM, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia-Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, AW, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, GP, Schantz, S, Simonato, L, Brenner, H, Conway, DI, Macfarlane, TV, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, SC, Lee, YCA, Hashibe, M & Boccia, S 2014, 'Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium', European Journal of Epidemiology, vol. 29, no. 1, pp. 35-48. https://doi.org/10.1007/s10654-013-9863-2

TY - JOUR

T1 - Adult height and head and neck cancer

T2 - A pooled analysis within the INHANCE Consortium

AU - Leoncini, Emanuele

AU - Ricciardi, Walter

AU - Cadoni, Gabriella

AU - Arzani, Dario

AU - Petrelli, Livia

AU - Paludetti, Gaetano

AU - Brennan, Paul

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Matsuo, Keitaro

AU - Talamini, Renato

AU - La Vecchia, Carlo

AU - Olshan, Andrew F.

AU - Winn, Deborah M.

AU - Herrero, Rolando

AU - Franceschi, Silvia

AU - Castellsague, Xavier

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Zhang, Zuo Feng

AU - Levi, Fabio

AU - Dal Maso, Luigino

AU - Kelsey, Karl

AU - McClean, Michael

AU - Vaughan, Thomas L.

AU - Lazarus, Philip

AU - Purdue, Mark P.

AU - Hayes, Richard B.

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Shangina, Oxana

AU - Koifman, Sergio

AU - Ahrens, Wolfgang

AU - Matos, Elena

AU - Lagiou, Pagona

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Fernandez, Leticia

AU - Menezes, Ana

AU - Agudo, Antonio

AU - Daudt, Alexander W.

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Mates, Dana

AU - Betka, Jaroslav

AU - Yu, Guo Pei

AU - Schantz, Stimson

AU - Simonato, Lorenzo

AU - Brenner, Hermann

AU - Conway, David I.

AU - Macfarlane, Tatiana V.

AU - Thomson, Peter

AU - Fabianova, Eleonora

AU - Znaor, Ariana

AU - Rudnai, Peter

AU - Healy, Claire

AU - Boffetta, Paolo

AU - Chuang, Shu Chun

AU - Lee, Yuan Chin Amy

AU - Hashibe, Mia

AU - Boccia, Stefania

N1 - Funding Information: The authors would like to thank all of the participants who took part in this research for providing us very insightful and constructive comments, which helped improve this manuscript. The individual studies were supported by the following grants: Central Europe study: World Cancer Research Fund and the European Commission INCO-COPERNICUS Program (IC15- CT98-0332). France study (2001–2007): French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Association for Research on Cancer (ARC); Fondation pour la Recherche Médicale (FRM); French Institute for Public Health Surveillance (InVS); Fondation de France; Ministry of Labour; Ministry of Health. Saarland study: Ministry of Science, Research and Arts Baden-Wurttemberg. Aviano study: Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research. Milan study (1984–1989): Italian Association for Research on Cancer (AIRC). Milan study (2006–2009): Italian Association for Research on Cancer (AIRC, grant n. 10068) and Italian Ministry of Education (PRIN 2009 X8YCBN). Italy Multicenter study: Italian Association for Research on Cancer (AIRC), Italian League Against Cancer and Italian Ministry of Research. Rome study (2010–2013): AIRC (Italian Agency for Research on Cancer), n. 10491. Swiss study: Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse (KFS-700, OCS-1633). Western Europe study: European Community (5th Framework Programme) (QLK1-CT-2001-00182). Boston study: National Institutes of Health (NIH) US (R01CA078609, R01CA100679). Los Angeles study: National Institute of Health (NIH) US (P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667) and the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center. MSKCC study: NIH (R01CA051845). New York Multicenter study: National Institutes of Health (NIH) US (P01CA068384 K07CA104231). North Carolina (1994–1997): National Institutes of Health (NIH) US (R01CA061188), and in part by a grant from the National Institute of Environmental Health Sciences (P30ES010126). Seattle-LEO study: NIH (R01CA030022). Seattle study: National Institutes of Health (NIH) US (R01CA048996, R01DE012609). Tampa study: National Institutes of Health (NIH) US (P01CA068384, K07CA104231, R01DE013158). US Multicenter study: The Intramural Program of the NCI, NIH, United States. Puerto Rico study: jointly funded by National Institutes of Health (NCI) US and NIDCR intramural programs. Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a' Pesquisa no Estado de Sao Paulo (FAPESP) (No 01/01768-2), and European Commission (IC18-CT97-0222). Japan (1988–2000 and 2001–2005): Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan (17015052) and grant for the Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan (H20-002). IARC Multicenter study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government (FIS 97/0024, FIS 97/0662, BAE 01/5013), International Union Against Cancer (UICC), and Yamagiwa-Yoshida Memorial International Cancer Study Grant. The work of EL was supported by Fondazione Veronesi.

PY - 2014/1

Y1 - 2014/1

N2 - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

AB - Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

UR - http://www.scopus.com/inward/record.url?scp=84896899629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896899629&partnerID=8YFLogxK

U2 - 10.1007/s10654-013-9863-2

DO - 10.1007/s10654-013-9863-2

M3 - Article

C2 - 24271556

AN - SCOPUS:84896899629

SN - 0393-2990

VL - 29

SP - 35

EP - 48

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

IS - 1

ER -

Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium

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