Advanced Cell and Tissue Biomanufacturing

Kaiming Ye, David L. Kaplan, Gang Bao, Christopher Bettinger, Gabor Forgacs, Cheng Dong, Ali Khademhosseini, Yonggang Ke, Kam Leong, Athanassios Sambanis, Wei Sun, Peng Yin

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


This position paper assesses state-of-the-art advanced biomanufacturing and identifies paths forward to advance this emerging field in biotechnology and biomedical engineering, including new research opportunities and translational and corporate activities. The vision for the field is to see advanced biomanufacturing emerge as a discipline in academic and industrial communities as well as a technological opportunity to spur research and industry growth. To navigate this vision, the paths to move forward and to identify major barriers were a focal point of discussions at a National Science Foundation-sponsored workshop focused on the topic. Some of the major needs include but are not limited to the integration of specific scientific and engineering disciplines and guidance from regulatory agencies, infrastructure requirements, and strategies for reliable systems integration. Some of the recommendations, major targets, and opportunities were also outlined, including some "grand challenges" to spur interest and progress in the field based on the participants at the workshop. Many of these recommendations have been expanded, materialized, and adopted by the field. For instance, the formation of an initial collaboration network in the community was established. This report provides suggestions for the opportunities and challenges to help move the field of advanced biomanufacturing forward. The field is in the early stages of effecting science and technology in biomanufacturing with a bright and important future impact evident based on the rapid scientific advances in recent years and industry progress.

Original languageEnglish (US)
Pages (from-to)2292-2307
Number of pages16
JournalACS Biomaterials Science and Engineering
Issue number7
StatePublished - Jul 9 2018

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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