TY - JOUR
T1 - Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos
T2 - A 10-year retrospective review
AU - Rao, Hridya
AU - Weiss, Margaret C.
AU - Moon, Jee Young
AU - Perreira, Krista M.
AU - Daviglus, Martha L.
AU - Kaplan, Robert
AU - North, Kari E.
AU - Argos, Maria
AU - Fernández-Rhodes, Lindsay
AU - Sofer, Tamar
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/1/9
Y1 - 2025/1/9
N2 - The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
AB - The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
UR - https://www.scopus.com/pages/publications/85209253405
UR - https://www.scopus.com/inward/citedby.url?scp=85209253405&partnerID=8YFLogxK
U2 - 10.1016/j.xhgg.2024.100376
DO - 10.1016/j.xhgg.2024.100376
M3 - Review article
C2 - 39473183
AN - SCOPUS:85209253405
SN - 2666-2477
VL - 6
JO - Human Genetics and Genomics Advances
JF - Human Genetics and Genomics Advances
IS - 1
M1 - 100376
ER -
