Advances in epitope mapping technologies for food protein allergens: A review

Fanlin Zhou, Shudong He, Hanju Sun, Yongfei Wang, Yi Zhang

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Background: The incidence of food allergy has been increasing in recent years, but the prevention, diagnosis, and treatment of food allergy remain challenges in the world. Food allergen epitope mapping technology can help us identify the epitope sequence and structure, which is conducive to the development of food allergy prevention, diagnosis, and treatment methods. Moreover, the information about allergic epitopes also plays a positive role in the development of new hypoallergenic or non-allergenic food products in the industry. Scope and approach: This article systematically reviews state-of-art research progress and development trend of food epitope mapping technology based on the advantages and disadvantages as well as the potentials of each method. The future development direction and trend of food protein allergen epitope mapping technology were also discussed, with a view to providing a reference for the identification and characterization of food allergens. Key findings and conclusions: Compared with traditional technologies including peptide scanning technique, novel technologies have the advantages of high specificity, high sensitivity, high accuracy, and high-throughput. Although some progress has been made in the identification and characterization of food protein allergen epitopes, a large number of epitopes have not yet been identified so far. Some work is still needed for invention of new epitope mapping technology, establishment of systematic and comprehensive databases, and development of allergic omics in the future.

Original languageEnglish (US)
Pages (from-to)226-239
Number of pages14
JournalTrends in Food Science and Technology
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science


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