TY - JOUR
T1 - Advances in epitope mapping technologies for food protein allergens
T2 - A review
AU - Zhou, Fanlin
AU - He, Shudong
AU - Sun, Hanju
AU - Wang, Yongfei
AU - Zhang, Yi
N1 - Funding Information:
The authors are grateful for the financial support from the National Natural Science Foundation of China (No. 31701524 ), Chengdu Technological Innovation Research and Development Project, China (No. 2019-YF05-00965-SN ), the Anhui Key Research and Development Program, China (No. 201904a06020030 ) and 2019 CAST Outstanding Chinese and Foreign Youth Exchange Program, China.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Background: The incidence of food allergy has been increasing in recent years, but the prevention, diagnosis, and treatment of food allergy remain challenges in the world. Food allergen epitope mapping technology can help us identify the epitope sequence and structure, which is conducive to the development of food allergy prevention, diagnosis, and treatment methods. Moreover, the information about allergic epitopes also plays a positive role in the development of new hypoallergenic or non-allergenic food products in the industry. Scope and approach: This article systematically reviews state-of-art research progress and development trend of food epitope mapping technology based on the advantages and disadvantages as well as the potentials of each method. The future development direction and trend of food protein allergen epitope mapping technology were also discussed, with a view to providing a reference for the identification and characterization of food allergens. Key findings and conclusions: Compared with traditional technologies including peptide scanning technique, novel technologies have the advantages of high specificity, high sensitivity, high accuracy, and high-throughput. Although some progress has been made in the identification and characterization of food protein allergen epitopes, a large number of epitopes have not yet been identified so far. Some work is still needed for invention of new epitope mapping technology, establishment of systematic and comprehensive databases, and development of allergic omics in the future.
AB - Background: The incidence of food allergy has been increasing in recent years, but the prevention, diagnosis, and treatment of food allergy remain challenges in the world. Food allergen epitope mapping technology can help us identify the epitope sequence and structure, which is conducive to the development of food allergy prevention, diagnosis, and treatment methods. Moreover, the information about allergic epitopes also plays a positive role in the development of new hypoallergenic or non-allergenic food products in the industry. Scope and approach: This article systematically reviews state-of-art research progress and development trend of food epitope mapping technology based on the advantages and disadvantages as well as the potentials of each method. The future development direction and trend of food protein allergen epitope mapping technology were also discussed, with a view to providing a reference for the identification and characterization of food allergens. Key findings and conclusions: Compared with traditional technologies including peptide scanning technique, novel technologies have the advantages of high specificity, high sensitivity, high accuracy, and high-throughput. Although some progress has been made in the identification and characterization of food protein allergen epitopes, a large number of epitopes have not yet been identified so far. Some work is still needed for invention of new epitope mapping technology, establishment of systematic and comprehensive databases, and development of allergic omics in the future.
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U2 - 10.1016/j.tifs.2020.10.035
DO - 10.1016/j.tifs.2020.10.035
M3 - Review article
AN - SCOPUS:85095824088
SN - 0924-2244
VL - 107
SP - 226
EP - 239
JO - Trends in Food Science and Technology
JF - Trends in Food Science and Technology
ER -