TY - JOUR
T1 - Advances in multidisciplinary therapy for meningiomas
AU - International Consortium on Meningiomas
AU - Brastianos, Priscilla K.
AU - Galanis, Evanthia
AU - Butowski, Nicholas
AU - Chan, Jason W.
AU - Dunn, Ian F.
AU - Goldbrunner, Roland
AU - Herold-Mende, Christel
AU - Ippen, Franziska M.
AU - Mawrin, Christian
AU - McDermott, Michael W.
AU - Sloan, Andrew
AU - Snyder, James
AU - Tabatabai, Ghazaleh
AU - Tatagiba, Marcos
AU - Tonn, Joerg C.
AU - Wen, Patrick Y.
AU - Aldape, Kenneth
AU - Nassiri, Farshad
AU - Zadeh, Gelareh
AU - Jenkinson, Michael D.
AU - Raleigh, David R.
AU - Au, Karolyn
AU - Barnhartz-Sloan, Jill
AU - Bi, Wenya Linda
AU - Carlotti, Carlos
AU - Cusimano, Michael D.
AU - Dimeco, Francesco
AU - Drummond, Katharine
AU - Giannini, Caterina
AU - Griffith, Brent
AU - Hashizume, Rintaro
AU - Hanemann, C. Oliver
AU - Horbinski, Craig
AU - Huang, Raymond Y.
AU - James, David
AU - Jungk, Christine
AU - Kaufman, Timothy J.
AU - Krischek, Boris
AU - Lachance, Daniel
AU - Lafougère, Christian
AU - Lee, Ian
AU - Liu, Jeff C.
AU - Mamatjan, Yasin
AU - Mansouri, Alireza
AU - Munoz, David
AU - Noushmehr, Houtan
AU - Ng, Ho Keung
AU - Perry, Arie
AU - Pirouzmand, Farhad
AU - Poisson, Laila M.
N1 - Publisher Copyright:
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved.
PY - 2019/1/14
Y1 - 2019/1/14
N2 - Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-Institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.
AB - Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-Institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.
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U2 - 10.1093/neuonc/noy136
DO - 10.1093/neuonc/noy136
M3 - Article
C2 - 30649489
AN - SCOPUS:85060012470
SN - 1522-8517
VL - 21
SP - I18-I31
JO - Neuro-oncology
JF - Neuro-oncology
ER -