Advances in the role of follicular T helper cells in graft versus host diseases

Maogen Chen; Xiaohong Lin; Julie Wang; Nancy Olsen; Song Guo Zheng

doi:10.1016/j.livres.2017.06.001

Advances in the role of follicular T helper cells in graft versus host diseases

Maogen Chen, Xiaohong Lin, Julie Wang, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journal › Review article › peer-review

Abstract

Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases. Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis. Cells producing the cytokine, interleukin (IL)-21 are crucial players involved in injured tissues in GVHD patients. Besides T helper 17 cells, follicular T helper (Tfh) cells are a new source of IL-21 and play a vital role in GVHD pathogenesis. Tfh cell function is mostly regulated by T-follicular regulatory (Tfr) cells that are also located in the germinal center. This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis. New insights are provided into the potential for clinical application in GVHD prevention and treatment.

Original language	English (US)
Pages (from-to)	131-134
Number of pages	4
Journal	Liver Research
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.livres.2017.06.001
State	Published - Sep 2017

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

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10.1016/j.livres.2017.06.001

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title = "Advances in the role of follicular T helper cells in graft versus host diseases",

abstract = "Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases. Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis. Cells producing the cytokine, interleukin (IL)-21 are crucial players involved in injured tissues in GVHD patients. Besides T helper 17 cells, follicular T helper (Tfh) cells are a new source of IL-21 and play a vital role in GVHD pathogenesis. Tfh cell function is mostly regulated by T-follicular regulatory (Tfr) cells that are also located in the germinal center. This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis. New insights are provided into the potential for clinical application in GVHD prevention and treatment.",

author = "Maogen Chen and Xiaohong Lin and Julie Wang and Nancy Olsen and Zheng, {Song Guo}",

note = "Publisher Copyright: {\textcopyright} 2017 The Third Affiliated Hospital of Sun Yat-sen University",

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T1 - Advances in the role of follicular T helper cells in graft versus host diseases

AU - Chen, Maogen

AU - Lin, Xiaohong

AU - Wang, Julie

AU - Olsen, Nancy

AU - Zheng, Song Guo

PY - 2017/9

Y1 - 2017/9

N2 - Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases. Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis. Cells producing the cytokine, interleukin (IL)-21 are crucial players involved in injured tissues in GVHD patients. Besides T helper 17 cells, follicular T helper (Tfh) cells are a new source of IL-21 and play a vital role in GVHD pathogenesis. Tfh cell function is mostly regulated by T-follicular regulatory (Tfr) cells that are also located in the germinal center. This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis. New insights are provided into the potential for clinical application in GVHD prevention and treatment.

AB - Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases. Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis. Cells producing the cytokine, interleukin (IL)-21 are crucial players involved in injured tissues in GVHD patients. Besides T helper 17 cells, follicular T helper (Tfh) cells are a new source of IL-21 and play a vital role in GVHD pathogenesis. Tfh cell function is mostly regulated by T-follicular regulatory (Tfr) cells that are also located in the germinal center. This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis. New insights are provided into the potential for clinical application in GVHD prevention and treatment.

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JO - Liver Research

JF - Liver Research

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Advances in the role of follicular T helper cells in graft versus host diseases

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