Advances in understanding pulmonary host defense mechanisms: Dendritic cell function and immunomodulation

Herbert Y. Reynolds, J. Lloyd Huck

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Mucosal host immunity in the respiratory tract can probably be manipulated to better improve defense against microbes and other antigens or particulates that cause infection and respiratory illness. An evolving strategy is to target the extensive network of dendritic cells in the lungs, especially dendritic cells located in the airway epithelium, which are super antigen-presenting cells that can initiate specific T-lymphocyte immune responses. Also, dendritic cells can elaborate cytokines such as interleukin 1 2 which drive other components of the immune response including antibody production. However, dendritic cells can be counter-regulated by inhibitory cytokines or certain microbes that create a dynamic interplay. This review emphasizes human studies and relevant animal models that provide a framework for future planning of experimental approaches to enhancing antimicrobial immunity and respiratory host defense. (C) 2000 Lippincott Williams and Wilkins, Inc.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalCurrent opinion in pulmonary medicine
Issue number3
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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