TY - JOUR
T1 - Advances in vasospasm treatment and prevention
AU - Komotar, Ricardo J.
AU - Zacharia, Brad E.
AU - Valhora, Ricky
AU - Mocco, J.
AU - Connolly, E. Sander
PY - 2007/10/15
Y1 - 2007/10/15
N2 - Outcome after aSAH depends on several factors, including the severity of the initial event, perioperative medical management, surgical variables, and the incidence of complications. Cerebral vasospasm (CV) is ure to consistently respond to treatment, emphasizing the need for further research into the underlying mechanisms of SAH-induced cerebrovascular dysfunction. To this end, our paper reviews the relevant literature on the main therapies employed for CV after aSAH and discusses possible avenues for future investigations. Current management of this condition consists of maximal medical therapy, including triple H regimen and oral administration of calcium antagonists, followed by endovascular balloon angioplasty and/or injection of vasodilatory agents for refractory cases. As the precise pathophysiology of CV is further elucidated, the development of promising investigational therapies will follow.
AB - Outcome after aSAH depends on several factors, including the severity of the initial event, perioperative medical management, surgical variables, and the incidence of complications. Cerebral vasospasm (CV) is ure to consistently respond to treatment, emphasizing the need for further research into the underlying mechanisms of SAH-induced cerebrovascular dysfunction. To this end, our paper reviews the relevant literature on the main therapies employed for CV after aSAH and discusses possible avenues for future investigations. Current management of this condition consists of maximal medical therapy, including triple H regimen and oral administration of calcium antagonists, followed by endovascular balloon angioplasty and/or injection of vasodilatory agents for refractory cases. As the precise pathophysiology of CV is further elucidated, the development of promising investigational therapies will follow.
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U2 - 10.1016/j.jns.2007.04.046
DO - 10.1016/j.jns.2007.04.046
M3 - Article
C2 - 17570400
AN - SCOPUS:34548147894
SN - 0022-510X
VL - 261
SP - 134
EP - 142
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1-2
ER -