TY - JOUR
T1 - Advancing botanical safety
T2 - A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
AU - Waidyanatha, Suramya
AU - Collins, Bradley J.
AU - Cristy, Tim
AU - Embry, Michelle
AU - Gafner, Stefan
AU - Johnson, Holly
AU - Kellogg, Josh
AU - Krzykwa, Julie
AU - Li, Siheng
AU - Mitchell, Constance A.
AU - Mutlu, Esra
AU - Pickett, Sarah
AU - You, Hong
AU - Van Breemen, Richard
AU - Baker, Timothy R.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/4
Y1 - 2024/4
N2 - Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. However, botanicals present unique challenges for safety assessment due to their complex and variable composition arising from diverse growing conditions, processing methods, and plant varieties. Historically, botanicals have been largely evaluated based on their history of use information, based primarily on traditional use or dietary history. However, this presumption lacks comprehensive toxicological evaluation, demanding innovative and consistent assessment strategies. To address these challenges, the Botanical Safety Consortium (BSC) was formed as an international, cross-sector forum of experts to identify fit-for purpose assays that can be used to evaluate botanical safety. This global effort aims to assess botanical safety assessment methodologies, merging traditional knowledge with modern in vitro and in silico assays. The ultimate goal is to champion the development of toxicity tools for botanicals. This manuscript highlights: 1) BSC's strategy for botanical selection, sourcing, and preparation of extracts to be used in in vitro assays, and 2) the approach utilized to characterize botanical extracts, using green tea and Asian ginseng as examples, to build confidence for use in biological assays.
AB - Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. However, botanicals present unique challenges for safety assessment due to their complex and variable composition arising from diverse growing conditions, processing methods, and plant varieties. Historically, botanicals have been largely evaluated based on their history of use information, based primarily on traditional use or dietary history. However, this presumption lacks comprehensive toxicological evaluation, demanding innovative and consistent assessment strategies. To address these challenges, the Botanical Safety Consortium (BSC) was formed as an international, cross-sector forum of experts to identify fit-for purpose assays that can be used to evaluate botanical safety. This global effort aims to assess botanical safety assessment methodologies, merging traditional knowledge with modern in vitro and in silico assays. The ultimate goal is to champion the development of toxicity tools for botanicals. This manuscript highlights: 1) BSC's strategy for botanical selection, sourcing, and preparation of extracts to be used in in vitro assays, and 2) the approach utilized to characterize botanical extracts, using green tea and Asian ginseng as examples, to build confidence for use in biological assays.
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U2 - 10.1016/j.fct.2024.114537
DO - 10.1016/j.fct.2024.114537
M3 - Article
C2 - 38417538
AN - SCOPUS:85188083513
SN - 0278-6915
VL - 186
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 114537
ER -