Adverse drug reaction to methotrexate: Pharmacogenetic origin

Peter R. Przekop, Henry Tulgan, Allison A. Przekop, Michael Glantz

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Recent advances in molecular biology have provided physicians with genetic testing strategies that can be used to predict adverse drug reactions (ADRs). Many ADRs can be linked to single-nucleotide polymorphisms in genes that control aspects of drug disposition. We report a case in which a standard dose of methotrexate resulted in life-threatening mucositis, neutropenia, and thrombocytopenia in a 61-year-old woman. The patient was found to have a genetic anomaly in an enzyme that plays a key role in folate metabolism. Methotrexate is known to deplete folate levels. As data accumulate and genetic testing strategies improve, it should be possible to predict ADRs in individual patients, thereby resulting in better patient care and a reduction in medical expenditures.

Original languageEnglish (US)
Pages (from-to)706-707
Number of pages2
JournalThe Journal of the American Osteopathic Association
Issue number12
StatePublished - Dec 2006

All Science Journal Classification (ASJC) codes

  • General Medicine


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