African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

Yuehai Ke, Bing Su, Xiufeng Song, Daru Lu, Lifeng Chen, Hongyu Li, Chunjian Qi, Sangkot Marzuki, Ranjan Deka, Peter Underhill, Chunjie Xiao, Mark Shriver, Jeff Lell, Douglas Wallace, R. Spencer Wells, Mark Seielstad, Peter Oefner, Dingliang Zhu, Jianzhong Jin, Wei HuangRanajit Chakraborty, Zhu Chen, Li Jin

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Original languageEnglish (US)
Pages (from-to)1151-1153
Number of pages3
Issue number5519
StatePublished - May 11 2001

All Science Journal Classification (ASJC) codes

  • General


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