African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

Yuehai Ke; Bing Su; Xiufeng Song; Daru Lu; Lifeng Chen; Hongyu Li; Chunjian Qi; Sangkot Marzuki; Ranjan Deka; Peter Underhill; Chunjie Xiao; Mark Shriver; Jeff Lell; Douglas Wallace; R. Spencer Wells; Mark Seielstad; Peter Oefner; Dingliang Zhu; Jianzhong Jin; Wei Huang; Ranajit Chakraborty; Zhu Chen; Li Jin

doi:10.1126/science.1060011

African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

Yuehai Ke
, Bing Su
, Xiufeng Song
, Daru Lu
, Lifeng Chen
, Hongyu Li
, Chunjian Qi
, Sangkot Marzuki
, Ranjan Deka
, Peter Underhill
, Chunjie Xiao
, Mark Shriver
, Jeff Lell
, Douglas Wallace
, R. Spencer Wells
, Mark Seielstad
, Peter Oefner
, Dingliang Zhu
, Jianzhong Jin
, Wei Huang

Ranajit Chakraborty, Zhu Chen, Li Jin

Anthropology

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Original language	English (US)
Pages (from-to)	1151-1153
Number of pages	3
Journal	Science
Volume	292
Issue number	5519
DOIs	https://doi.org/10.1126/science.1060011
State	Published - May 11 2001

All Science Journal Classification (ASJC) codes

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Ke, Y., Su, B., Song, X., Lu, D., Chen, L., Li, H., Qi, C., Marzuki, S., Deka, R., Underhill, P., Xiao, C., Shriver, M., Lell, J., Wallace, D., Wells, R. S., Seielstad, M., Oefner, P., Zhu, D., Jin, J., ... Jin, L. (2001). African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes. Science, 292(5519), 1151-1153. https://doi.org/10.1126/science.1060011

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title = "African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes",

abstract = "To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.",

author = "Yuehai Ke and Bing Su and Xiufeng Song and Daru Lu and Lifeng Chen and Hongyu Li and Chunjian Qi and Sangkot Marzuki and Ranjan Deka and Peter Underhill and Chunjie Xiao and Mark Shriver and Jeff Lell and Douglas Wallace and Wells, \{R. Spencer\} and Mark Seielstad and Peter Oefner and Dingliang Zhu and Jianzhong Jin and Wei Huang and Ranajit Chakraborty and Zhu Chen and Li Jin",

year = "2001",

month = may,

day = "11",

doi = "10.1126/science.1060011",

language = "English (US)",

volume = "292",

pages = "1151--1153",

journal = "Science",

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Ke, Y, Su, B, Song, X, Lu, D, Chen, L, Li, H, Qi, C, Marzuki, S, Deka, R, Underhill, P, Xiao, C, Shriver, M, Lell, J, Wallace, D, Wells, RS, Seielstad, M, Oefner, P, Zhu, D, Jin, J, Huang, W, Chakraborty, R, Chen, Z & Jin, L 2001, 'African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes', Science, vol. 292, no. 5519, pp. 1151-1153. https://doi.org/10.1126/science.1060011

TY - JOUR

T1 - African origin of modern humans in East Asia

T2 - A tale of 12,000 Y chromosomes

AU - Ke, Yuehai

AU - Su, Bing

AU - Song, Xiufeng

AU - Lu, Daru

AU - Chen, Lifeng

AU - Li, Hongyu

AU - Qi, Chunjian

AU - Marzuki, Sangkot

AU - Deka, Ranjan

AU - Underhill, Peter

AU - Xiao, Chunjie

AU - Shriver, Mark

AU - Lell, Jeff

AU - Wallace, Douglas

AU - Wells, R. Spencer

AU - Seielstad, Mark

AU - Oefner, Peter

AU - Zhu, Dingliang

AU - Jin, Jianzhong

AU - Huang, Wei

AU - Chakraborty, Ranajit

AU - Chen, Zhu

AU - Jin, Li

PY - 2001/5/11

Y1 - 2001/5/11

N2 - To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

AB - To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

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VL - 292

SP - 1151

EP - 1153

JO - Science

JF - Science

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ER -

African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

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