African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

  • Yuehai Ke
  • , Bing Su
  • , Xiufeng Song
  • , Daru Lu
  • , Lifeng Chen
  • , Hongyu Li
  • , Chunjian Qi
  • , Sangkot Marzuki
  • , Ranjan Deka
  • , Peter Underhill
  • , Chunjie Xiao
  • , Mark Shriver
  • , Jeff Lell
  • , Douglas Wallace
  • , R. Spencer Wells
  • , Mark Seielstad
  • , Peter Oefner
  • , Dingliang Zhu
  • , Jianzhong Jin
  • , Wei Huang
  • Ranajit Chakraborty, Zhu Chen, Li Jin

Research output: Contribution to journalArticlepeer-review

179 Scopus citations

Abstract

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Original languageEnglish (US)
Pages (from-to)1151-1153
Number of pages3
JournalScience
Volume292
Issue number5519
DOIs
StatePublished - May 11 2001

All Science Journal Classification (ASJC) codes

  • General

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