TY - JOUR
T1 - Age and stage as determinants of treatment for oral cavity and oropharyngeal cancers in the elderly
AU - Goldenberg, David
AU - Mackley, Heath
AU - Koch, Wayne
AU - Bann, Darrin V.
AU - Schaefer, Eric W.
AU - Hollenbeak, Christopher S.
N1 - Funding Information:
This study was supported by a Grant ( 5 R03 DEOOO019511 ) from the National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR).
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5%); most patients with OP cancer were treated with chemotherapy and radiation (28.9%). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95% CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.
AB - Background We investigate treatment selection for oral cavity and oropharyngeal (OC&OP) cancers to understand factors that influence treatment selection. Methods We studied 7023 patients, ≥66 years, diagnosed with a first primary OC&OP cancer using SEER-Medicare data. Multinomial logistic regression was to model treatment selection, controlling for other factors. Results Most patients with OC cancer were treated with surgery alone (56.5%); most patients with OP cancer were treated with chemotherapy and radiation (28.9%). Age, stage and site were the most important predictors of treatment selection. As age increased from 70 to 81 (the interquartile range), treatment shifted toward surgery alone (OR = 1.26; CI: 1.08-1.46) and no treatment (OR = 1.5, 95% CI: 1.25-1.80), and away from combined surgery, radiation and treatments involving chemotherapy. Conclusions Age, stage, and site are the most important determinants of treatment selection for patients with OC&OP cancers. Increasing age and stage drive treatment toward non-surgical options and no treatment at all.
UR - https://www.scopus.com/pages/publications/84907861945
UR - https://www.scopus.com/pages/publications/84907861945#tab=citedBy
U2 - 10.1016/j.oraloncology.2014.07.008
DO - 10.1016/j.oraloncology.2014.07.008
M3 - Article
C2 - 25153476
AN - SCOPUS:84907861945
SN - 1368-8375
VL - 50
SP - 976
EP - 982
JO - Oral Oncology
JF - Oral Oncology
IS - 10
ER -
