Age-related changes in the efficacy of crystalloid cardioplegia

James A. Magovern, Walter Pae, John A. Waldhausen

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4 Scopus citations


Recent work has shown that multi-dose St. Thomas' Hospital cardioplegia solution (STHC) may not provide reliable protection of the neonatal myocardium. We have used an isolated working heart model to study the age-related development of this observation. Sets of eight hearts from 2-, 4-, 6-, and 8-week-old rabbits were subjected to 90 min of ischemia at 10°C. STHC was infused at 30-min intervals in a dose of 10 ml/kg. There were no differences in the preservation of ATP stores during ischemia among the groups. The percentage recovery of preischemic mean aortic pressure, left atrial pressure, and heart rate were not different among groups, but the percentage recovery of aortic flow (AF) (expressed as means ± standard error of the mean) was significantly lower in the 2- and 4-week hearts (44.1 ± 8.2 and 66.2 ± 7.7%) than in the 6- and 8-week hearts (93.0 ± 6.4 and 97.6 ± 4.7%). We have confirmed that the use of multi-dose STHC impairs recovery of ventricular function in the neonatal rabbit heart. This effect, however, diminishes rapidly as the immature animal develops and is not present by 6 weeks of age. Additional experimentation is necessary to identify those aspects of the developing myocardium that account for these observations.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalJournal of Surgical Research
Issue number3
StatePublished - Sep 1991

All Science Journal Classification (ASJC) codes

  • Surgery


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