Age-related differences in the metabolic response to injury

David Frankenfield, Robert N. Cooney, J. Stanley Smith, William A. Rowe

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Objective: To investigate the effect of age on the metabolic response to injury. Methods: Fifty-two trauma patients meeting entrance criteria were prospectively enrolled. Patients were grouped by age: elderly, >60 years; and young, ≤60 years. After 4 days of nutrition support, physiologic and laboratory data were collected. Energy and nitrogen metabolism, and body composition were evaluated. Results: Elderly patients demonstrated a reduced incidence of fever (48% vs. 77%, p = 0.027). Independent of body composition, temperature, and injury severity, oxygen consumption was 8% lower in the elderly (p = 0.0032). However, nitrogen loss and myofibrillar catabolic rate was not altered by age. Elderly subjects were more often hyperglycemic (38% vs. 0%, p < 0.0001) and azotemic (62% vs. 22%, p = 0.004), despite similar carbohydrate and protein intake. Conclusion: Fever is less common and oxygen consumption lower in elderly trauma patients. Postinjury myofibrillar protein catabolism and nitrogen loss are not influenced by aging. Metabolic complications of nutrition support (hyperglycemia, azotemia) are more common in elderly trauma patients.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number1
StatePublished - Jan 2000

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine


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