TY - JOUR
T1 - Aging in the olfactory system
AU - Mobley, Arie S.
AU - Rodriguez-Gil, Diego J.
AU - Imamura, Fumiaki
AU - Greer, Charles A.
N1 - Funding Information:
Supported in part by National Institutes of Health (NIH) National Institute on Deafness and Other Communication Disorders (NIDCD) DC000210 to C.A.G., DC012130 to A.S.M., DC010894 to D.J.R-G., and DC011134 to F.I. The authors thank all members of the lab for helpful discussions.
PY - 2014/2
Y1 - 2014/2
N2 - With advancing age, the ability of humans to detect and discriminate odors declines. In light of the rapid progress in analyzing molecular and structural correlates of developing and adult olfactory systems, the paucity of information available on the aged olfactory system is startling. A rich literature documents the decline of olfactory acuity in aged humans, but the underlying cellular and molecular mechanisms are largely unknown. Using animal models, preliminary work is beginning to uncover differences between young and aged rodents that may help address the deficits seen in humans, but many questions remain unanswered. Recent studies of odorant receptor (OR) expression, synaptic organization, adult neurogenesis, and the contribution of cortical representation during aging suggest possible underlying mechanisms and new research directions.
AB - With advancing age, the ability of humans to detect and discriminate odors declines. In light of the rapid progress in analyzing molecular and structural correlates of developing and adult olfactory systems, the paucity of information available on the aged olfactory system is startling. A rich literature documents the decline of olfactory acuity in aged humans, but the underlying cellular and molecular mechanisms are largely unknown. Using animal models, preliminary work is beginning to uncover differences between young and aged rodents that may help address the deficits seen in humans, but many questions remain unanswered. Recent studies of odorant receptor (OR) expression, synaptic organization, adult neurogenesis, and the contribution of cortical representation during aging suggest possible underlying mechanisms and new research directions.
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U2 - 10.1016/j.tins.2013.11.004
DO - 10.1016/j.tins.2013.11.004
M3 - Review article
C2 - 24361044
AN - SCOPUS:84893649721
SN - 0166-2236
VL - 37
SP - 77
EP - 84
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 2
ER -