Alanine peak in central neurocytomas on proton MR spectroscopy

Krishnamoorthy Thamburaj; V. V. Radhakrishnan; B. Thomas; E. R. Jeyadevan; G. Menon; Suresh Nair

doi:10.1007/s00234-007-0224-2

Alanine peak in central neurocytomas on proton MR spectroscopy

Krishnamoorthy Thamburaj, V. V. Radhakrishnan, B. Thomas, E. R. Jeyadevan, G. Menon, Suresh Nair

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22 Scopus citations

Abstract

Introduction: We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine. Materials and methods: Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining. Results: With an echotime of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients. Conclusion: Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.

Original language	English (US)
Pages (from-to)	551-554
Number of pages	4
Journal	Neuroradiology
Volume	49
Issue number	7
DOIs	https://doi.org/10.1007/s00234-007-0224-2
State	Published - Jul 2007

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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title = "Alanine peak in central neurocytomas on proton MR spectroscopy",

abstract = "Introduction: We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine. Materials and methods: Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining. Results: With an echotime of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients. Conclusion: Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.",

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T1 - Alanine peak in central neurocytomas on proton MR spectroscopy

AU - Thamburaj, Krishnamoorthy

AU - Radhakrishnan, V. V.

AU - Thomas, B.

AU - Jeyadevan, E. R.

AU - Menon, G.

AU - Nair, Suresh

PY - 2007/7

Y1 - 2007/7

N2 - Introduction: We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine. Materials and methods: Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining. Results: With an echotime of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients. Conclusion: Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.

AB - Introduction: We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine. Materials and methods: Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining. Results: With an echotime of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients. Conclusion: Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.

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Alanine peak in central neurocytomas on proton MR spectroscopy

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