Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Laurel R. Seemiller; Julio Flores-Cuadra; Keith R. Griffith; Grace C. Smith; Nicole A. Crowley

doi:10.1016/j.ynstr.2024.100605

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Laurel R. Seemiller, Julio Flores-Cuadra, Keith R. Griffith, Grace C. Smith, Nicole A. Crowley

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.

Original language	English (US)
Article number	100605
Journal	Neurobiology of Stress
Volume	29
DOIs	https://doi.org/10.1016/j.ynstr.2024.100605
State	Published - Mar 2024

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Molecular Biology
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ynstr.2024.100605

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title = "Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline",

abstract = "Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.",

author = "Seemiller, {Laurel R.} and Julio Flores-Cuadra and Griffith, {Keith R.} and Smith, {Grace C.} and Crowley, {Nicole A.}",

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AU - Seemiller, Laurel R.

AU - Flores-Cuadra, Julio

AU - Griffith, Keith R.

AU - Smith, Grace C.

AU - Crowley, Nicole A.

PY - 2024/3

Y1 - 2024/3

N2 - Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.

AB - Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global health initiatives. Efforts to prevent the development of ADRD require understanding behaviors that increase and decrease risk of neurodegeneration and cognitive decline, in addition to uncovering the underlying biological mechanisms behind these effects. Stress exposure and alcohol consumption have both been associated with increased risk for ADRD in human populations. However, our ability to understand causal mechanisms of ADRD requires substantial preclinical research. In this review, we summarize existing human and animal research investigating the connections between lifetime stress and alcohol exposures and ADRD.

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JO - Neurobiology of Stress

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Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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