Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases α and β

Keyphrases

• Polymerase 100%
• Alkylation 100%
• DNA Synthesis 100%
• DNA Polymerase 100%
• Frameshift 100%
• Mutagenesis 100%
• N-ethyl-N-nitrosourea 66%
• Primase 50%
• Frameshift mutation 50%
• Repetitive Sequences 33%
• Non-repetitive 33%
• Single-stranded DNA (ssDNA) 16%
• Fold Increase 16%
• Mutation Frequency 16%
• Frequency Dependence 16%
• Mutagens 16%
• Guanine 16%
• Base Substitution 16%
• DNA Template 16%
• Alkylating Agents 16%
• Transition mutation 16%
• Polymerase Reaction 16%
• Herpes Simplex Virus Thymidine Kinase 16%
• Transition Frequency 16%
• Monofunctional 16%
• Base Deletion 16%
• Repetitive DNA Sequences 16%
• Mispairing 16%
• Mutational Spectrum 16%
• Solvent Control 16%
• Mutational Event 16%
• Polymerase mutants 16%

Biochemistry, Genetics and Molecular Biology

• Polymerase 100%
• DNA Synthesis 100%
• Alkylation 100%
• Mutagenesis 100%
• DNA Polymerase 100%
• DNA Template 75%
• Primase 37%
• Frameshift Mutation 37%
• Single-Stranded DNA 12%
• Guanine 12%
• Nucleic Acid Base Substitution 12%
• Mutation Rate 12%
• Thymidine Kinase 12%
• Herpes Simplex Virus 12%
• Repetitive DNA Sequences 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Mutagenesis 100%
• Nitrosourea 100%
• DNA Polymerase 100%
• Base 50%
• Mutagenic Agent 25%
• Thymidine Kinase 25%
• Single Stranded DNA 25%
• Alkylating Agent 25%
• Guanine 25%
• Herpes Simplex Virus 25%