Alkylation of messenger RNA by dimethylnitrosamine

Anthony Pegg, Ann Jackson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Rats were treated with radioactive dimethylnitrosamine or methyl methanesulphonate and the alkylation of various RNA fractions was determined 4 h later. It was found that after administration of dimethylnitrosamine, hepatic messenger RNA (isolated by binding to oligo(dT)-cellulose) and nuclear RNA were alkylated slightly, but significantly less than ribosomal RNA. After treatment with methyl methanesulphonate nuclear RNA was alkylated to a greater extent than either messenger or ribosomal RNA. The implications of these findings with respect to the mechanism by which dimethylnitrosamine inhibits liver protein synthesis are discussed.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalChemico-Biological Interactions
Issue number3-4
StatePublished - Jan 1 1976

All Science Journal Classification (ASJC) codes

  • Toxicology


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