Altered mechanisms of thermoregulatory vasoconstriction in aged human skin

Caitlin S. Thompson-Torgerson, Lacy A. Holowatz, W. Larry Kenney

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalExercise and Sport Sciences Reviews
Issue number3
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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