Altered mechanisms of vasodilation in aged human skin

Lacy A. Holowatz, Caitlin S. Thompson-Torgerson, W. Larry Kenney

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Human skin blood flow increases in response to increased body core and local skin temperature via distinct reflex and local mechanisms requiring functional nitric oxide (NO) for full expression. The mechanisms mediating cutaneous vasodilation are impaired with primary aging, resulting in attenuated vasodilation. This article highlights recent findings of how age-related vascular impairments in NO signaling contribute to attenuated cutaneous vasodilation.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalExercise and Sport Sciences Reviews
Issue number3
StatePublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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