Altered physiology of gastrointestinal vagal afferents following neurotrauma

Emily Blanke, Gregory Holmes, Emily Besecker

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The adaptability of the central nervous system has been revealed in several model systems. Of particular interest to central nervous system-injured individuals is the ability for neural components to be modified for regain of function. In both types of neurotrauma, traumatic brain injury and spinal cord injury, the primary parasympathetic control to the gastrointestinal tract, the vagus nerve, remains anatomically intact. However, individuals with traumatic brain injury or spinal cord injury are highly susceptible to gastrointestinal dysfunctions. Such gastrointestinal dysfunctions attribute to higher morbidity and mortality following traumatic brain injury and spinal cord injury. While the vagal efferent output remains capable of eliciting motor responses following injury, evidence suggests impairment of the vagal afferents. Since sensory input drives motor output, this review will discuss the normal and altered anatomy and physiology of the gastrointestinal vagal afferents to better understand the contributions of vagal afferent plasticity following neurotrauma.

Original languageEnglish (US)
Pages (from-to)254-263
Number of pages10
JournalNeural Regeneration Research
Issue number2
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience


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