TY - JOUR
T1 - Altering phosphorylation in cancer through PP2A modifiers
AU - Johnson, Hannah
AU - Narayan, Satya
AU - Sharma, Arun K.
N1 - Publisher Copyright:
© 2024, The Author(s).
PY - 2024/12
Y1 - 2024/12
N2 - Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promoting tumor progression. Considerable research has been undertaken to discover molecules capable of modulating PP2A activity in cancer. Because PP2A is capable of immense substrate specificity across many cellular processes, the therapeutic targeting of PP2A in cancer can be completed through either enzyme inhibitors or activators. PP2A modulators likewise tend to be effective in drug-resistant cancers and work synergistically with other known cancer therapeutics. In this review, we will discuss the patterns of PP2A deregulation in cancer, and its known downstream signaling pathways important for cancer regulation, along with many activators and inhibitors of PP2A known to inhibit cancer progression.
AB - Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promoting tumor progression. Considerable research has been undertaken to discover molecules capable of modulating PP2A activity in cancer. Because PP2A is capable of immense substrate specificity across many cellular processes, the therapeutic targeting of PP2A in cancer can be completed through either enzyme inhibitors or activators. PP2A modulators likewise tend to be effective in drug-resistant cancers and work synergistically with other known cancer therapeutics. In this review, we will discuss the patterns of PP2A deregulation in cancer, and its known downstream signaling pathways important for cancer regulation, along with many activators and inhibitors of PP2A known to inhibit cancer progression.
UR - http://www.scopus.com/inward/record.url?scp=85181499373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85181499373&partnerID=8YFLogxK
U2 - 10.1186/s12935-023-03193-1
DO - 10.1186/s12935-023-03193-1
M3 - Review article
C2 - 38184584
AN - SCOPUS:85181499373
SN - 1475-2867
VL - 24
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 11
ER -