Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone

Keyphrases

• 3-Methylcatechol 27%
• 4-Methylcatechol 9%
• Active Site Engineering 100%
• Alpha Subunit 9%
• Benzene 9%
• Burkholderia Cepacia 9%
• Catalytic Center 9%
• Catechol 9%
• Cresol 63%
• Diiron 9%
• Directed Evolution 9%
• Homology Modeling 9%
• Hydrogen Bonding Interaction 9%
• Hydroxyl Group 9%
• Hydroxylase 9%
• I100 9%
• M-Cresol 18%
• Methoxyphenols 54%
• Methylhydroquinone 100%
• Monooxygenase 9%
• New Reactions 9%
• Ortho 9%
• Oxidation Rate 9%
• Oxygenase 9%
• P-Cresol 36%
• Pseudomonas Mendocina 9%
• Regioselective Oxidation 9%
• Regiospecific 18%
• Regiospecificity 18%
• Saturation mutagenesis 18%
• Structure Homology 9%
• Toluene 36%
• Toluene Dioxygenase 100%
• Toluene Oxidation 9%
• Trihydroxybenzene 9%
• Vmax 9%

Pharmacology, Toxicology and Pharmaceutical Science

• 4 Methylcatechol 8%
• Burkholderia cepacia 8%
• Catechol 8%
• Cresol 33%
• Guaiacol 75%
• Hydroxyl Group 8%
• Meta cresol 8%
• Mutagenesis 16%
• Ortho Cresol 58%
• Oxygenase 33%
• Phenol 8%
• Pseudomonas mendocina 8%
• Pyrogallol 8%
• Unspecific Monooxygenase 100%

Chemistry

• 3-Methylcatechol 25%
• 4-Methylcatechol 8%
• Oxygenase Reaction 8%