TY - JOUR
T1 - Alternatives for measuring endogenous adrenocortical activity in asthmatics treated with inhaled corticosteroids
AU - Buyantseva, Larisa V.
AU - Chinchilli, Vernon M.
AU - Tulchinsky, Mark
AU - Bascom, Rebecca
AU - Martin, Richard J.
N1 - Funding Information:
The authors are grateful to Dr. Thomas Lloyd for his kind mentoring of the primary author and to Linda Engle for skillful preparation of statistical illustrations. Vernon M. Chinchilli and Richard J. Martin were supported in this work by grants U10 HL-51845 and U10 HL-51834, respectively, from the National Heart, Lung, and Blood Institute.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - We compared a 12-hour, hourly integrated plasma cortisol profile in asthmatics treated with a corticosteroids with a variety of modified methods based on less frequent blood sampling. Excellent agreement with the reference was observed for sampling at 10 p.m. and 8 a.m. (correlation coefficient of 0.97; 95% confidence interval 0.97, 0.98); at 9 p.m. and 7 a.m. (r = 0.95; 0.94, 0.96); at 11 p.m. and 7 a.m. (r = 0.94; 0.93, 0.95); every 2 hours (r = 0.96; 0.96, 0.97); and every 3 hours (r = 0.91, 0.91, 0.93). The two-sample alternatives (10 p.m/8 a.m. and 9 p.m/7 a.m.) are accurate, as well as more convenient, economical, and practical.
AB - We compared a 12-hour, hourly integrated plasma cortisol profile in asthmatics treated with a corticosteroids with a variety of modified methods based on less frequent blood sampling. Excellent agreement with the reference was observed for sampling at 10 p.m. and 8 a.m. (correlation coefficient of 0.97; 95% confidence interval 0.97, 0.98); at 9 p.m. and 7 a.m. (r = 0.95; 0.94, 0.96); at 11 p.m. and 7 a.m. (r = 0.94; 0.93, 0.95); every 2 hours (r = 0.96; 0.96, 0.97); and every 3 hours (r = 0.91, 0.91, 0.93). The two-sample alternatives (10 p.m/8 a.m. and 9 p.m/7 a.m.) are accurate, as well as more convenient, economical, and practical.
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U2 - 10.1080/07435800500406148
DO - 10.1080/07435800500406148
M3 - Article
C2 - 16433245
AN - SCOPUS:32144456194
SN - 0743-5800
VL - 31
SP - 245
EP - 258
JO - Endocrine Research
JF - Endocrine Research
IS - 4
ER -