TY - JOUR
T1 - Ambulatory assessment for precision psychiatry
T2 - Foundations, current developments and future avenues
AU - Reichert, Markus
AU - Gan, Gabriela
AU - Renz, Malika
AU - Braun, Urs
AU - Brüßler, Sarah
AU - Timm, Irina
AU - Ma, Ren
AU - Berhe, Oksana
AU - Benedyk, Anastasia
AU - Moldavski, Alexander
AU - Schweiger, Janina I.
AU - Hennig, Oliver
AU - Zidda, Francesca
AU - Heim, Christine
AU - Banaschewski, Tobias
AU - Tost, Heike
AU - Ebner-Priemer, Ulrich W.
AU - Meyer-Lindenberg, Andreas
N1 - Funding Information:
To date, there are only a few empirical studies demonstrating the efficacy of the use of wearables in the therapeutic field. In addition, wearables and smartphones, if used for therapy or diagnostics, are covered by the German medical devices law (Medizinproduktgesetz - MPG). However, most of these devices or apps have not been developed for this purpose and may therefore not be used for MPG approval studies. Fortunately, the first projects in Germany tackling this issue are being supported by the funding agencies. Examples are the BMBF (Federal Ministry of Education and Research, Germany) project „TherapyBuilder“, which is a generic software platform for the setup of medical product-compliant smartphone apps, as well as for the systematic evaluation of smartphone-based interventions, which is envisaged in the second funding period of the ReCoDe study described above. Accordingly, the first step on a long road to routinely using evidence-based ambulatory assessment interventions for clinical practice has been taken. This is highly promising, especially since mobile systems can identify the context and mechanisms in everyday life and real-time, and they can intervene throughout 24 h a day.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/11
Y1 - 2021/11
N2 - Precision psychiatry stands to benefit from the latest digital technologies for assessment and analyses to tailor treatment towards individuals. Insights into dynamic psychological processes as they unfold in humans' everyday life can critically add value in understanding symptomatology and environmental stressors to provide individualized treatment where and when needed. Towards this goal, ambulatory assessment encompasses methodological approaches to investigate behavioral, physiological, and biological processes in humans' everyday life. It combines repeated assessments of symptomatology over time, e.g., via Ecological Momentary Assessment (e.g., smartphone-diaries), with monitoring of physical behavior, environmental characteristics (such as geolocations, social interactions) and physiological function via sensors, e.g., mobile accelerometers, global-positioning-systems, and electrocardiography. In this review, we expand on promises of ambulatory assessment in the investigation of mental states (e.g., real-life, dynamical and contextual perspective), on chances for precision psychiatry such as the prediction of courses of psychiatric disorders, detection of tipping points and critical windows of relapse, and treatment effects as exemplified by ongoing projects, and on future avenues of how ambulatory interventions can benefit personalized care for psychiatric patients (e.g., through real-time feedback in everyday life). Ambulatory assessment is a key contributor to precision psychiatry, opening up promising avenues in research, diagnoses, prevention and treatment.
AB - Precision psychiatry stands to benefit from the latest digital technologies for assessment and analyses to tailor treatment towards individuals. Insights into dynamic psychological processes as they unfold in humans' everyday life can critically add value in understanding symptomatology and environmental stressors to provide individualized treatment where and when needed. Towards this goal, ambulatory assessment encompasses methodological approaches to investigate behavioral, physiological, and biological processes in humans' everyday life. It combines repeated assessments of symptomatology over time, e.g., via Ecological Momentary Assessment (e.g., smartphone-diaries), with monitoring of physical behavior, environmental characteristics (such as geolocations, social interactions) and physiological function via sensors, e.g., mobile accelerometers, global-positioning-systems, and electrocardiography. In this review, we expand on promises of ambulatory assessment in the investigation of mental states (e.g., real-life, dynamical and contextual perspective), on chances for precision psychiatry such as the prediction of courses of psychiatric disorders, detection of tipping points and critical windows of relapse, and treatment effects as exemplified by ongoing projects, and on future avenues of how ambulatory interventions can benefit personalized care for psychiatric patients (e.g., through real-time feedback in everyday life). Ambulatory assessment is a key contributor to precision psychiatry, opening up promising avenues in research, diagnoses, prevention and treatment.
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U2 - 10.1016/j.expneurol.2021.113807
DO - 10.1016/j.expneurol.2021.113807
M3 - Article
C2 - 34228998
AN - SCOPUS:85111992959
SN - 0014-4886
VL - 345
JO - Experimental Neurology
JF - Experimental Neurology
M1 - 113807
ER -