Amended Safety Assessment of Isethionate Salts as Used in Cosmetics

Christina L. Burnett; Bart Heldreth; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen; Lillian J. Gill

doi:10.1177/1091581816685552

Amended Safety Assessment of Isethionate Salts as Used in Cosmetics

Christina L. Burnett, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Although there are data gaps, the shared chemical core structure, expected similarities in physicochemical properties, and similar functions and concentrations in cosmetics enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each ingredient.

Original language	English (US)
Pages (from-to)	5S-16S
Journal	International journal of toxicology
Volume	36
Issue number	1_suppl
DOIs	https://doi.org/10.1177/1091581816685552
State	Published - May 1 2017

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581816685552

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Burnett, C. L., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2017). Amended Safety Assessment of Isethionate Salts as Used in Cosmetics. International journal of toxicology, 36(1_suppl), 5S-16S. https://doi.org/10.1177/1091581816685552

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title = "Amended Safety Assessment of Isethionate Salts as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Although there are data gaps, the shared chemical core structure, expected similarities in physicochemical properties, and similar functions and concentrations in cosmetics enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each ingredient.",

author = "Burnett, {Christina L.} and Bart Heldreth and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan} and Gill, {Lillian J.}",

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AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

AU - Gill, Lillian J.

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AB - The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Although there are data gaps, the shared chemical core structure, expected similarities in physicochemical properties, and similar functions and concentrations in cosmetics enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each ingredient.

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Amended Safety Assessment of Isethionate Salts as Used in Cosmetics

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All Science Journal Classification (ASJC) codes

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