Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, David Cohen, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of Methylisothiazolinone, which functions as a preservative in cosmetics. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0.01%) and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment or similar methodology.

Original languageEnglish (US)
Pages (from-to)5S-19S
JournalInternational journal of toxicology
Issue number1_suppl
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Toxicology


Dive into the research topics of 'Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics'. Together they form a unique fingerprint.

Cite this