Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett; Ivan Boyer; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; Lillian J. Gill; Bart Heldreth

doi:10.1177/1091581819838792

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett
, Ivan Boyer
, Wilma F. Bergfeld
, Donald V. Belsito
, Ronald A. Hill
, Curtis D. Klaassen
, Daniel C. Liebler
, James G. Marks
, Ronald C. Shank
, Thomas J. Slaga
, Paul W. Snyder
, Lillian J. Gill
, Bart Heldreth

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Original language	English (US)
Pages (from-to)	70S-84S
Journal	International Journal of Toxicology
Volume	38
Issue number	1_suppl
DOIs	https://doi.org/10.1177/1091581819838792
State	Published - May 1 2019

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581819838792

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Burnett, C. L., Boyer, I., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Gill, L. J., & Heldreth, B. (2019). Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. International Journal of Toxicology, 38(1_suppl), 70S-84S. https://doi.org/10.1177/1091581819838792

@article{b388702962f34a63a02ad3836376a3cd,

title = "Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.",

author = "Burnett, \{Christina L.\} and Ivan Boyer and Bergfeld, \{Wilma F.\} and Belsito, \{Donald V.\} and Hill, \{Ronald A.\} and Klaassen, \{Curtis D.\} and Liebler, \{Daniel C.\} and Marks, \{James G.\} and Shank, \{Ronald C.\} and Slaga, \{Thomas J.\} and Snyder, \{Paul W.\} and Gill, \{Lillian J.\} and Bart Heldreth",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

month = may,

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doi = "10.1177/1091581819838792",

language = "English (US)",

volume = "38",

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T1 - Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

AU - Burnett, Christina L.

AU - Boyer, Ivan

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Gill, Lillian J.

AU - Heldreth, Bart

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: © The Author(s) 2019.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

AB - The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

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UR - https://www.scopus.com/pages/publications/85067185200#tab=citedBy

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AN - SCOPUS:85067185200

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VL - 38

SP - 70S-84S

JO - International Journal of Toxicology

JF - International Journal of Toxicology

IS - 1_suppl

ER -

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Abstract

All Science Journal Classification (ASJC) codes

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