Amino acids as regulators of gene expression

Scot R. Kimball, Leonard S. Jefferson

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways.

Original languageEnglish (US)
JournalNutrition and Metabolism
StatePublished - Aug 17 2004

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Medicine (miscellaneous)


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