TY - JOUR
T1 - Amino acids as regulators of gene expression at the level of mRNA translation
AU - Jefferson, Leonard S.
AU - Kimball, Scot R.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Amino acids act through a number of signaling pathways and mechanisms to mediate control of gene expression at the level of mRNA translation. This report reviews recent findings that illustrate the manner through which amino acids act to regulate the initiation phase of mRNA translation. The report focuses on signaling pathways that involve the eukaryotic initiation factor-2 (elF2) protein kinase, general control non-derepressing kinase-2 and the mammalian target of rapamycin (mTOR) protein kinase. It also describes the mechanisms through which amino acid-induced modulation of elF2 phosphorylation and mTOR-mediated signaling cause derepression of translation of specific mRNAs and result in an overall change in the pattern of gene expression. Finally, it provides examples of mRNAs whose translation is modulated through these mechanisms.
AB - Amino acids act through a number of signaling pathways and mechanisms to mediate control of gene expression at the level of mRNA translation. This report reviews recent findings that illustrate the manner through which amino acids act to regulate the initiation phase of mRNA translation. The report focuses on signaling pathways that involve the eukaryotic initiation factor-2 (elF2) protein kinase, general control non-derepressing kinase-2 and the mammalian target of rapamycin (mTOR) protein kinase. It also describes the mechanisms through which amino acid-induced modulation of elF2 phosphorylation and mTOR-mediated signaling cause derepression of translation of specific mRNAs and result in an overall change in the pattern of gene expression. Finally, it provides examples of mRNAs whose translation is modulated through these mechanisms.
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U2 - 10.1093/jn/133.6.2046s
DO - 10.1093/jn/133.6.2046s
M3 - Article
C2 - 12771363
AN - SCOPUS:0037712737
SN - 0022-3166
VL - 133
SP - 2046S-2051S
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 6 SUPPL. 1
ER -