Amiodarone: Pharmacology and Antiarrhythmic and Adverse Effects

Gerald V. Naccarelli, Robert L. Rinkenberger, Anne H. Dougherty, Ruth A. Giebel

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half‐life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2‐compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life‐threatening arrhythmias. 1985 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)298-311
Number of pages14
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume5
Issue number6
DOIs
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

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