TY - JOUR
T1 - Amiodarone
T2 - Pharmacology and Antiarrhythmic and Adverse Effects
AU - Naccarelli, Gerald V.
AU - Rinkenberger, Robert L.
AU - Dougherty, Anne H.
AU - Giebel, Ruth A.
PY - 1985
Y1 - 1985
N2 - Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half‐life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2‐compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life‐threatening arrhythmias. 1985 Pharmacotherapy Publications Inc.
AB - Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half‐life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2‐compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life‐threatening arrhythmias. 1985 Pharmacotherapy Publications Inc.
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U2 - 10.1002/j.1875-9114.1985.tb03434.x
DO - 10.1002/j.1875-9114.1985.tb03434.x
M3 - Article
C2 - 2934688
AN - SCOPUS:0022347632
SN - 0277-0008
VL - 5
SP - 298
EP - 311
JO - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
JF - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
IS - 6
ER -